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pubmed-article:16717432pubmed:issue5lld:pubmed
pubmed-article:16717432pubmed:dateCreated2006-5-23lld:pubmed
pubmed-article:16717432pubmed:abstractTextThe aim of the current study was to investigate the metabolism of (-)-menthone by liver microsomes of humans. (-)-Menthone (1) was metabolized to (+)-neomenthol (2) (3-reduction) and 7-hydroxymenthone (3) by human liver microsomes. The metabolites formed were analyzed on GC and GC-MS. Kinetic analysis showed that K(m) and V(max) values for the metabolized (-)-menthone to respective (+)-neomenthol and 7-hydroxymenthone by liver microsomes of human sample HG70 were 0.37 mM and 4.91 nmol/min/mg protein and 0.07 mM and 0.71 nmol/min/mg protein.lld:pubmed
pubmed-article:16717432pubmed:languageenglld:pubmed
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pubmed-article:16717432pubmed:statusMEDLINElld:pubmed
pubmed-article:16717432pubmed:monthMaylld:pubmed
pubmed-article:16717432pubmed:issn0916-8451lld:pubmed
pubmed-article:16717432pubmed:authorpubmed-author:MiyazawaMitsu...lld:pubmed
pubmed-article:16717432pubmed:authorpubmed-author:NakanishiKyou...lld:pubmed
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pubmed-article:16717432pubmed:volume70lld:pubmed
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pubmed-article:16717432pubmed:pagination1259-61lld:pubmed
pubmed-article:16717432pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:16717432pubmed:year2006lld:pubmed
pubmed-article:16717432pubmed:articleTitleBiotransformation of (-)-menthone by human liver microsomes.lld:pubmed
pubmed-article:16717432pubmed:affiliationDepartment of Applied Chemistry, Faculty of Science and Engineering, Kinki University, Osaka, Japan. miyazawa@apch.kindai.ac.jplld:pubmed
pubmed-article:16717432pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16717432pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed