| pubmed-article:16714381 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16714381 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:16714381 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:16714381 | lifeskim:mentions | umls-concept:C0019425 | lld:lifeskim |
| pubmed-article:16714381 | lifeskim:mentions | umls-concept:C0007994 | lld:lifeskim |
| pubmed-article:16714381 | lifeskim:mentions | umls-concept:C1422009 | lld:lifeskim |
| pubmed-article:16714381 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:16714381 | lifeskim:mentions | umls-concept:C0033422 | lld:lifeskim |
| pubmed-article:16714381 | lifeskim:mentions | umls-concept:C0205359 | lld:lifeskim |
| pubmed-article:16714381 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:16714381 | pubmed:dateCreated | 2006-5-31 | lld:pubmed |
| pubmed-article:16714381 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16714381 | pubmed:abstractText | Homology between p63 and p53 has suggested that these proteins might function similarly. However, the majority of data from human tumors have not supported a similar role for p63 in tumor suppression. To investigate this issue, we studied spontaneous tumorigenesis in p63+/- mice in both WT and p53-compromised backgrounds. We found that p63+/- mice were not tumor prone and mice heterozygous for both p63 and p53 had fewer tumors than p53+/- mice. The rare tumors that developed in mice with compromised p63 were also distinct from those of p53+/- mice. Furthermore, p63+/- mice were not prone to chemically induced tumorigenesis, and p63 expression was maintained in carcinomas. These findings demonstrate that, in agreement with data from human tumors, p63 plays a markedly different biological role in cancer than p53. | lld:pubmed |
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| pubmed-article:16714381 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16714381 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16714381 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16714381 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16714381 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16714381 | pubmed:month | May | lld:pubmed |
| pubmed-article:16714381 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:16714381 | pubmed:author | pubmed-author:PUYR JRJ | lld:pubmed |
| pubmed-article:16714381 | pubmed:author | pubmed-author:BradleyAllanA | lld:pubmed |
| pubmed-article:16714381 | pubmed:author | pubmed-author:RoopDennis... | lld:pubmed |
| pubmed-article:16714381 | pubmed:author | pubmed-author:MillsAlea AAA | lld:pubmed |
| pubmed-article:16714381 | pubmed:author | pubmed-author:VogelHannesH | lld:pubmed |
| pubmed-article:16714381 | pubmed:author | pubmed-author:KeyesWilliam... | lld:pubmed |
| pubmed-article:16714381 | pubmed:author | pubmed-author:GuoXuecuiX | lld:pubmed |
| pubmed-article:16714381 | pubmed:author | pubmed-author:KosterMaranke... | lld:pubmed |
| pubmed-article:16714381 | pubmed:author | pubmed-author:PetherbridgeK... | lld:pubmed |
| pubmed-article:16714381 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16714381 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:16714381 | pubmed:volume | 103 | lld:pubmed |
| pubmed-article:16714381 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16714381 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16714381 | pubmed:pagination | 8435-40 | lld:pubmed |
| pubmed-article:16714381 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:16714381 | pubmed:meshHeading | pubmed-meshheading:16714381... | lld:pubmed |
| pubmed-article:16714381 | pubmed:meshHeading | pubmed-meshheading:16714381... | lld:pubmed |
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| pubmed-article:16714381 | pubmed:meshHeading | pubmed-meshheading:16714381... | lld:pubmed |
| pubmed-article:16714381 | pubmed:meshHeading | pubmed-meshheading:16714381... | lld:pubmed |
| pubmed-article:16714381 | pubmed:meshHeading | pubmed-meshheading:16714381... | lld:pubmed |
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| pubmed-article:16714381 | pubmed:meshHeading | pubmed-meshheading:16714381... | lld:pubmed |
| pubmed-article:16714381 | pubmed:meshHeading | pubmed-meshheading:16714381... | lld:pubmed |
| pubmed-article:16714381 | pubmed:meshHeading | pubmed-meshheading:16714381... | lld:pubmed |
| pubmed-article:16714381 | pubmed:meshHeading | pubmed-meshheading:16714381... | lld:pubmed |
| pubmed-article:16714381 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16714381 | pubmed:articleTitle | p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors. | lld:pubmed |
| pubmed-article:16714381 | pubmed:affiliation | Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. | lld:pubmed |
