| pubmed-article:1670944 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1670944 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:1670944 | lifeskim:mentions | umls-concept:C0003315 | lld:lifeskim |
| pubmed-article:1670944 | lifeskim:mentions | umls-concept:C0023005 | lld:lifeskim |
| pubmed-article:1670944 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:1670944 | lifeskim:mentions | umls-concept:C0206120 | lld:lifeskim |
| pubmed-article:1670944 | lifeskim:mentions | umls-concept:C0872192 | lld:lifeskim |
| pubmed-article:1670944 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:1670944 | lifeskim:mentions | umls-concept:C1519755 | lld:lifeskim |
| pubmed-article:1670944 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:1670944 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1670944 | pubmed:dateCreated | 1991-2-19 | lld:pubmed |
| pubmed-article:1670944 | pubmed:abstractText | We have recently demonstrated that a single dose (200 J/m2) of UVB radiation abrogates the capacity of mouse epidermal Langerhans cells (LC) or splenic adherent cells (SAC) to present keyhole limpet hemocyanin (KLH) to Ag-specific, MHC-restricted CD4+ Th1 cells. In the present study we determined whether such Th1 unresponsiveness represented long-lasting immunologic tolerance. To address this question, Th1 were preincubated with KLH-pulsed UVB-LC or UVB-SAC, then isolated and restimulated with unirradiated APC (LC or SAC) plus KLH or with exogenous rIL-2 in the absence of APC. Preincubation with KLH and UVB-LC or UVB-SAC rendered Th1 unresponsive to subsequent restimulation with APC and KLH. In addition, such Th1 were defective in their autocrine IL-2 production, but could respond normally to exogenous rIL-2, indicating that unresponsiveness was due to functional inactivation and not to cell death. Th1 unresponsiveness was Ag-specific, MHC-restricted, and long lasting (greater than 16 days). In addition, it appears that Th1 unresponsiveness is not due to the release of soluble suppressor factors from UVB-LC or UVB-SAC because supernatants from such cells had no effect on Th1 proliferation. Addition of unirradiated allogeneic SAC during preincubation prevented the induction of unresponsiveness by UVB-LC or UVB-SAC, suggesting that UVB interferes with the capacity of LC or SAC to deliver a costimulatory signal(s) that can be provided by allogeneic SAC. We conclude that UVB can convert LC or SAC from immunogenic to tolerogenic APC. | lld:pubmed |
| pubmed-article:1670944 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1670944 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1670944 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1670944 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1670944 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1670944 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1670944 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1670944 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1670944 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:1670944 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:1670944 | pubmed:author | pubmed-author:TigelaarR ERE | lld:pubmed |
| pubmed-article:1670944 | pubmed:author | pubmed-author:BergstresserP... | lld:pubmed |
| pubmed-article:1670944 | pubmed:author | pubmed-author:SimonJ CJC | lld:pubmed |
| pubmed-article:1670944 | pubmed:author | pubmed-author:EdelbaumDD | lld:pubmed |
| pubmed-article:1670944 | pubmed:author | pubmed-author:CruzP DPDJr | lld:pubmed |
| pubmed-article:1670944 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1670944 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:1670944 | pubmed:volume | 146 | lld:pubmed |
| pubmed-article:1670944 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1670944 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1670944 | pubmed:pagination | 485-91 | lld:pubmed |
| pubmed-article:1670944 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1670944 | pubmed:meshHeading | pubmed-meshheading:1670944-... | lld:pubmed |
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| pubmed-article:1670944 | pubmed:meshHeading | pubmed-meshheading:1670944-... | lld:pubmed |
| pubmed-article:1670944 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1670944 | pubmed:articleTitle | Ultraviolet B radiation converts Langerhans cells from immunogenic to tolerogenic antigen-presenting cells. Induction of specific clonal anergy in CD4+ T helper 1 cells. | lld:pubmed |
| pubmed-article:1670944 | pubmed:affiliation | Department of Dermatology, University of Texas Southwestern Medical Center, Dallas 75235. | lld:pubmed |
| pubmed-article:1670944 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1670944 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1670944 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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