Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:16709157rdf:typepubmed:Citationlld:pubmed
pubmed-article:16709157lifeskim:mentionsumls-concept:C1425002lld:lifeskim
pubmed-article:16709157lifeskim:mentionsumls-concept:C1426060lld:lifeskim
pubmed-article:16709157lifeskim:mentionsumls-concept:C1159709lld:lifeskim
pubmed-article:16709157lifeskim:mentionsumls-concept:C0127400lld:lifeskim
pubmed-article:16709157lifeskim:mentionsumls-concept:C1363844lld:lifeskim
pubmed-article:16709157pubmed:issuePt 3lld:pubmed
pubmed-article:16709157pubmed:dateCreated2006-5-19lld:pubmed
pubmed-article:16709157pubmed:abstractTextMLN64 (metastatic lymph node 64) and MENTHO (MLN64 N-terminal homologue) are two late-endosomal proteins that share a conserved region of four transmembrane helices with three short intervening loops called the MENTAL domain (MLN64 N-terminal domain). This domain mediates MLN64 and MENTHO homo- and hetero-interactions, targets both proteins to late endosomes and binds cholesterol in vivo. In addition to the MENTAL domain, MLN64 contains a cholesterol-specific START domain [StAR (steroidogenic acute regulatory protein)-related lipid transfer domain]. The START domain is a protein module of approx. 210 residues that binds lipids, including sterols, and is present in 15 distinct proteins in mammals. Thus MLN64 and MENTHO define discrete cholesterol-containing subdomains within the membrane of late endosomes where they may function in cholesterol transport. The MENTAL domain might serve to maintain cholesterol at the membrane of late endosomes prior to its shuttle to cytoplasmic acceptor(s) through the START domain.lld:pubmed
pubmed-article:16709157pubmed:languageenglld:pubmed
pubmed-article:16709157pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16709157pubmed:citationSubsetIMlld:pubmed
pubmed-article:16709157pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16709157pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16709157pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16709157pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16709157pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16709157pubmed:statusMEDLINElld:pubmed
pubmed-article:16709157pubmed:monthJunlld:pubmed
pubmed-article:16709157pubmed:issn0300-5127lld:pubmed
pubmed-article:16709157pubmed:authorpubmed-author:TomasettoCClld:pubmed
pubmed-article:16709157pubmed:authorpubmed-author:AlpyFFlld:pubmed
pubmed-article:16709157pubmed:issnTypePrintlld:pubmed
pubmed-article:16709157pubmed:volume34lld:pubmed
pubmed-article:16709157pubmed:ownerNLMlld:pubmed
pubmed-article:16709157pubmed:authorsCompleteYlld:pubmed
pubmed-article:16709157pubmed:pagination343-5lld:pubmed
pubmed-article:16709157pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:16709157pubmed:meshHeadingpubmed-meshheading:16709157...lld:pubmed
pubmed-article:16709157pubmed:meshHeadingpubmed-meshheading:16709157...lld:pubmed
pubmed-article:16709157pubmed:meshHeadingpubmed-meshheading:16709157...lld:pubmed
pubmed-article:16709157pubmed:meshHeadingpubmed-meshheading:16709157...lld:pubmed
pubmed-article:16709157pubmed:meshHeadingpubmed-meshheading:16709157...lld:pubmed
pubmed-article:16709157pubmed:meshHeadingpubmed-meshheading:16709157...lld:pubmed
pubmed-article:16709157pubmed:meshHeadingpubmed-meshheading:16709157...lld:pubmed
pubmed-article:16709157pubmed:year2006lld:pubmed
pubmed-article:16709157pubmed:articleTitleMLN64 and MENTHO, two mediators of endosomal cholesterol transport.lld:pubmed
pubmed-article:16709157pubmed:affiliationIGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire), Département de Pathologie Moléculaire, UMR7104-CNRS/U596-INSERM/Université Louis Pasteur, Illkirch, CU de Strasbourg, France.lld:pubmed
pubmed-article:16709157pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16709157pubmed:publicationTypeReviewlld:pubmed
pubmed-article:16709157pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
entrez-gene:10948entrezgene:pubmedpubmed-article:16709157lld:entrezgene
entrez-gene:83930entrezgene:pubmedpubmed-article:16709157lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:16709157lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:16709157lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16709157lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16709157lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16709157lld:pubmed