| pubmed-article:16706617 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16706617 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:16706617 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:16706617 | lifeskim:mentions | umls-concept:C0370215 | lld:lifeskim |
| pubmed-article:16706617 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:16706617 | lifeskim:mentions | umls-concept:C1565850 | lld:lifeskim |
| pubmed-article:16706617 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:16706617 | pubmed:dateCreated | 2006-5-18 | lld:pubmed |
| pubmed-article:16706617 | pubmed:abstractText | Cellulose acetate 1,2-benzenedicarboxylate (CAP), a pharmaceutical excipient used for enteric film coating of capsules and tablets, was previously shown to have potent inhibitory activity against infection by human immunodeficiency virus type 1 (HIV-1) T cell line-adapted (TCLA) strains. In the present study, we determined the inhibitory activity of CAP against infection by cell-free and cell-associated primary HIV-1 isolates with distinct genotypes and biotypes in cervical explants, peripheral blood mononuclear cells (PBMCs), monocytederived macrophages (MDMs), and CEMx174 5.25M7 cells. CAP blocked infection by cell-free and cell-associated HIV-1 in cervical explants. It inhibited infection by cell-free primary HIV-1 isolates (clades A to G and group O) in PBMCs, MDMs, and CEMx174 5.25M7 cells and blocked transmissions of the cell-associated primary HIV-1 isolates from dendritic cells (DCs) to PBMCs, from MDMs to PBMCs, and from PBMCs to CEMx174 5.25M7 cells. The inhibitory activity of CAP on infection by the cell-free and cell-associated primary HIV-1 isolates is independent of viral subtypes and coreceptor usage. These data suggest that CAP is a good microbicide candidate that can be further developed for preventing sexual transmission of HIV-1. | lld:pubmed |
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| pubmed-article:16706617 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16706617 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16706617 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16706617 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16706617 | pubmed:month | May | lld:pubmed |
| pubmed-article:16706617 | pubmed:issn | 0889-2229 | lld:pubmed |
| pubmed-article:16706617 | pubmed:author | pubmed-author:LuHongH | lld:pubmed |
| pubmed-article:16706617 | pubmed:author | pubmed-author:NeurathA... | lld:pubmed |
| pubmed-article:16706617 | pubmed:author | pubmed-author:ZhaoQianQ | lld:pubmed |
| pubmed-article:16706617 | pubmed:author | pubmed-author:HeYuxianY | lld:pubmed |
| pubmed-article:16706617 | pubmed:author | pubmed-author:LiuShuwenS | lld:pubmed |
| pubmed-article:16706617 | pubmed:author | pubmed-author:ShattockRobin... | lld:pubmed |
| pubmed-article:16706617 | pubmed:author | pubmed-author:WallaceGregG | lld:pubmed |
| pubmed-article:16706617 | pubmed:author | pubmed-author:JiangB... | lld:pubmed |
| pubmed-article:16706617 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16706617 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:16706617 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16706617 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16706617 | pubmed:pagination | 411-8 | lld:pubmed |
| pubmed-article:16706617 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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| pubmed-article:16706617 | pubmed:meshHeading | pubmed-meshheading:16706617... | lld:pubmed |
| pubmed-article:16706617 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16706617 | pubmed:articleTitle | Cellulose acetate 1,2-benzenedicarboxylate inhibits infection by cell-free and cell-associated primary HIV-1 isolates. | lld:pubmed |
| pubmed-article:16706617 | pubmed:affiliation | Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York 10021, USA. | lld:pubmed |
| pubmed-article:16706617 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16706617 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16706617 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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