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pubmed-article:16705274pubmed:abstractTextA reversible electrical block of the pudendal nerves may provide a valuable method for restoration of urinary voiding in individuals with bladder-sphincter dyssynergia. This study quantified the stimulus parameters and effectiveness of high frequency (HFAC) sinusoidal waveforms on the pudendal nerves to produce block of the external urethral sphincter (EUS). A proximal electrode on the pudendal nerve after its exit from the sciatic notch was used to apply low frequency stimuli to evoke EUS contractions. HFAC at frequencies from 1 to 30 kHz with amplitudes from 1 to 10 V were applied through a conforming tripolar nerve cuff electrode implanted distally. Sphincter responses were recorded with a catheter mounted micro-transducer. A fast onset and reversible motor block was obtained over this range of frequencies. The HFAC block showed three phases: a high onset response, often a period of repetitive firing and usually a steady state of complete or partial block. A complete EUS block was obtained in all animals. The block thresholds showed a linear relationship with frequency. HFAC pudendal nerve stimulation effectively produced a quickly reversible block of evoked urethral sphincter contractions. The HFAC pudendal block could be a valuable tool in the rehabilitation of bladder-sphincter dyssynergia.lld:pubmed
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pubmed-article:16705274pubmed:authorpubmed-author:BhadraNarendr...lld:pubmed
pubmed-article:16705274pubmed:authorpubmed-author:BhadraNiloyNlld:pubmed
pubmed-article:16705274pubmed:authorpubmed-author:GustafsonKenn...lld:pubmed
pubmed-article:16705274pubmed:authorpubmed-author:KilgoreKevinKlld:pubmed
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pubmed-article:16705274pubmed:pagination180-7lld:pubmed
pubmed-article:16705274pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:16705274pubmed:year2006lld:pubmed
pubmed-article:16705274pubmed:articleTitleHigh frequency electrical conduction block of the pudendal nerve.lld:pubmed
pubmed-article:16705274pubmed:affiliationDepartment of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Wickenden, Cleveland OH 44106-7207, USA.lld:pubmed
pubmed-article:16705274pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16705274pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
pubmed-article:16705274pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed
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