| pubmed-article:16705164 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16705164 | lifeskim:mentions | umls-concept:C0024501 | lld:lifeskim |
| pubmed-article:16705164 | lifeskim:mentions | umls-concept:C0171961 | lld:lifeskim |
| pubmed-article:16705164 | lifeskim:mentions | umls-concept:C2698421 | lld:lifeskim |
| pubmed-article:16705164 | lifeskim:mentions | umls-concept:C0521428 | lld:lifeskim |
| pubmed-article:16705164 | lifeskim:mentions | umls-concept:C0521457 | lld:lifeskim |
| pubmed-article:16705164 | lifeskim:mentions | umls-concept:C0019868 | lld:lifeskim |
| pubmed-article:16705164 | lifeskim:mentions | umls-concept:C1417838 | lld:lifeskim |
| pubmed-article:16705164 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:16705164 | lifeskim:mentions | umls-concept:C1704686 | lld:lifeskim |
| pubmed-article:16705164 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:16705164 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:16705164 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:16705164 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:16705164 | pubmed:dateCreated | 2006-5-17 | lld:pubmed |
| pubmed-article:16705164 | pubmed:abstractText | The orphan nuclear receptor Ad4BP/SF-1 (adrenal 4 binding protein/steroidogenic factor 1) is essential for the proper development and function of reproductive and steroidogenic tissues. Although the expression of Ad4BP/SF-1 is specific for those tissues, the mechanisms underlying this tissue-specific expression remain unknown. In this study, we used transgenic mouse assays to examine the regulation of the tissue-specific expression of Ad4BP/SF-1. An investigation of the entire Ad4BP/SF-1 gene locus revealed a fetal adrenal enhancer (FAdE) in intron 4 containing highly conserved binding sites for Pbx-Prep, Pbx-Hox, and Ad4BP/SF-1. Transgenic assays revealed that the Ad4 sites, together with Ad4BP/SF-1, develop an autoregulatory loop and thereby maintain transcription, while the Pbx/Prep and Pbx/Hox sites initiate transcription prior to the establishment of the autoregulatory loop. Indeed, a limited number of Hox family members were found to be expressed in the adrenal primordia. Whether a true fetal-type adrenal cortex is present in mice remained controversial, and this argument was complicated by the postnatal development of the so-called X zone. Using transgenic mice with lacZ driven by the FAdE, we clearly identified a fetal adrenal cortex in mice, and the X zone is the fetal adrenal cells accumulated at the juxtamedullary region after birth. | lld:pubmed |
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| pubmed-article:16705164 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16705164 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16705164 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16705164 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16705164 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16705164 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16705164 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16705164 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:16705164 | pubmed:author | pubmed-author:OkumuraKatsuz... | lld:pubmed |
| pubmed-article:16705164 | pubmed:author | pubmed-author:ZubairMohamad... | lld:pubmed |
| pubmed-article:16705164 | pubmed:author | pubmed-author:MorohashiKen-... | lld:pubmed |
| pubmed-article:16705164 | pubmed:author | pubmed-author:IshiharaSator... | lld:pubmed |
| pubmed-article:16705164 | pubmed:author | pubmed-author:OkaSanaeS | lld:pubmed |
| pubmed-article:16705164 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16705164 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:16705164 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16705164 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16705164 | pubmed:pagination | 4111-21 | lld:pubmed |
| pubmed-article:16705164 | pubmed:dateRevised | 2010-9-16 | lld:pubmed |
| pubmed-article:16705164 | pubmed:meshHeading | pubmed-meshheading:16705164... | lld:pubmed |
| pubmed-article:16705164 | pubmed:meshHeading | pubmed-meshheading:16705164... | lld:pubmed |
| pubmed-article:16705164 | pubmed:meshHeading | pubmed-meshheading:16705164... | lld:pubmed |
| pubmed-article:16705164 | pubmed:meshHeading | pubmed-meshheading:16705164... | lld:pubmed |
