| pubmed-article:16705139 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16705139 | lifeskim:mentions | umls-concept:C0023185 | lld:lifeskim |
| pubmed-article:16705139 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:16705139 | lifeskim:mentions | umls-concept:C0814002 | lld:lifeskim |
| pubmed-article:16705139 | lifeskim:mentions | umls-concept:C0019564 | lld:lifeskim |
| pubmed-article:16705139 | lifeskim:mentions | umls-concept:C0678558 | lld:lifeskim |
| pubmed-article:16705139 | lifeskim:mentions | umls-concept:C1998811 | lld:lifeskim |
| pubmed-article:16705139 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16705139 | pubmed:dateCreated | 2006-6-2 | lld:pubmed |
| pubmed-article:16705139 | pubmed:abstractText | In the adult brain, the expression of NT-3 is largely confined to the hippocampal dentate gyrus (DG), an area exhibiting significant neurogenesis. Using a conditional mutant line in which the NT-3 gene is deleted in the brain, we investigated the role of NT-3 in adult neurogenesis, hippocampal plasticity, and memory. Bromodeoxyuridine (BrdU)-labeling experiments demonstrated that differentiation, rather than proliferation, of the neuronal precursor cells (NPCs) was significantly impaired in DG lacking NT-3. Triple labeling for BrdU, the neuronal marker NeuN, and the glial marker GFAP indicated that NT-3 affects the number of newly differentiated neurons, but not glia, in DG. Field recordings revealed a selective impairment in long-term potentiation (LTP) in the lateral, but not medial perforant path-granule neuron synapses. In parallel, the NT-3 mutant mice exhibited deficits in spatial memory tasks. In addition to identifying a novel role for NT-3 in adult NPC differentiation in vivo, our study provides a potential link between neurogenesis, dentate LTP, and spatial memory. | lld:pubmed |
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| pubmed-article:16705139 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16705139 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16705139 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16705139 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16705139 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16705139 | pubmed:issn | 1072-0502 | lld:pubmed |
| pubmed-article:16705139 | pubmed:author | pubmed-author:CuiTT | lld:pubmed |
| pubmed-article:16705139 | pubmed:author | pubmed-author:JaenischRudol... | lld:pubmed |
| pubmed-article:16705139 | pubmed:author | pubmed-author:BatesBrianB | lld:pubmed |
| pubmed-article:16705139 | pubmed:author | pubmed-author:AkbarianSchah... | lld:pubmed |
| pubmed-article:16705139 | pubmed:author | pubmed-author:ShimazuKazuhi... | lld:pubmed |
| pubmed-article:16705139 | pubmed:author | pubmed-author:ZhaoMingruiM | lld:pubmed |
| pubmed-article:16705139 | pubmed:author | pubmed-author:SakataKazukoK | lld:pubmed |
| pubmed-article:16705139 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16705139 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:16705139 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16705139 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16705139 | pubmed:pagination | 307-15 | lld:pubmed |
| pubmed-article:16705139 | pubmed:dateRevised | 2010-9-15 | lld:pubmed |
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