| pubmed-article:16697230 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16697230 | lifeskim:mentions | umls-concept:C0038170 | lld:lifeskim |
| pubmed-article:16697230 | lifeskim:mentions | umls-concept:C1692886 | lld:lifeskim |
| pubmed-article:16697230 | lifeskim:mentions | umls-concept:C0165519 | lld:lifeskim |
| pubmed-article:16697230 | lifeskim:mentions | umls-concept:C0439793 | lld:lifeskim |
| pubmed-article:16697230 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:16697230 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:16697230 | lifeskim:mentions | umls-concept:C0181586 | lld:lifeskim |
| pubmed-article:16697230 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:16697230 | pubmed:dateCreated | 2006-6-20 | lld:pubmed |
| pubmed-article:16697230 | pubmed:abstractText | Matrix metalloproteinases constitute a family of structurally related endopeptidases that are crucial for the normal turnover of the extracellular matrix. Elevated levels of MMP-9 have been demonstrated in synovial fluids of rheumatoid arthritis patients, and a correlation with the severity of the disease has been described. The aim of this study was to explore the impact of MMP-9 expression on joint inflammation and destruction in a model of bacterially induced septic arthritis. MMP-9 knock-out mice and C57Bl6 congenic controls were inoculated intravenously or intra-articularly with Staphylococcus aureus. Arthritis was evaluated clinically and by means of histology. Zymographic analyses were performed to study ex vivo induction of MMP-9 following exposure to S. aureus. The MMP-9 knock-out mice displayed a significantly higher frequency and severity, but not destructivity, of arthritis than did the wild-type mice. The knock-out mice also proved to harbour an increased number of bacteria locally in joints and systemically in kidneys, possibly by impaired extravasation and recruitment of leukocytes and a deficient early defence against infection. Our findings indicate that deficiency in MMP-9 increases the degree of joint inflammation due to decreased bacterial clearance. | lld:pubmed |
| pubmed-article:16697230 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16697230 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16697230 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16697230 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16697230 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16697230 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16697230 | pubmed:month | May | lld:pubmed |
| pubmed-article:16697230 | pubmed:issn | 1286-4579 | lld:pubmed |
| pubmed-article:16697230 | pubmed:author | pubmed-author:OpdenakkerGhi... | lld:pubmed |
| pubmed-article:16697230 | pubmed:author | pubmed-author:TarkowskiAndr... | lld:pubmed |
| pubmed-article:16697230 | pubmed:author | pubmed-author:StarckxSofieS | lld:pubmed |
| pubmed-article:16697230 | pubmed:author | pubmed-author:Quiding-Järbr... | lld:pubmed |
| pubmed-article:16697230 | pubmed:author | pubmed-author:BerginPhilipP | lld:pubmed |
| pubmed-article:16697230 | pubmed:author | pubmed-author:CalanderAnn-M... | lld:pubmed |
| pubmed-article:16697230 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16697230 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:16697230 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16697230 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16697230 | pubmed:pagination | 1434-9 | lld:pubmed |
| pubmed-article:16697230 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:16697230 | pubmed:meshHeading | pubmed-meshheading:16697230... | lld:pubmed |
| pubmed-article:16697230 | pubmed:meshHeading | pubmed-meshheading:16697230... | lld:pubmed |
| pubmed-article:16697230 | pubmed:meshHeading | pubmed-meshheading:16697230... | lld:pubmed |
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| pubmed-article:16697230 | pubmed:meshHeading | pubmed-meshheading:16697230... | lld:pubmed |
| pubmed-article:16697230 | pubmed:meshHeading | pubmed-meshheading:16697230... | lld:pubmed |
| pubmed-article:16697230 | pubmed:meshHeading | pubmed-meshheading:16697230... | lld:pubmed |
| pubmed-article:16697230 | pubmed:meshHeading | pubmed-meshheading:16697230... | lld:pubmed |
| pubmed-article:16697230 | pubmed:meshHeading | pubmed-meshheading:16697230... | lld:pubmed |
| pubmed-article:16697230 | pubmed:meshHeading | pubmed-meshheading:16697230... | lld:pubmed |
| pubmed-article:16697230 | pubmed:meshHeading | pubmed-meshheading:16697230... | lld:pubmed |
| pubmed-article:16697230 | pubmed:meshHeading | pubmed-meshheading:16697230... | lld:pubmed |
| pubmed-article:16697230 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16697230 | pubmed:articleTitle | Matrix metalloproteinase-9 (gelatinase B) deficiency leads to increased severity of Staphylococcus aureus-triggered septic arthritis. | lld:pubmed |
| pubmed-article:16697230 | pubmed:affiliation | Department of Rheumatology and Inflammation Research, University of Gothenburg, Guldhedsgatan 10A, S-413 46 Gothenburg, Sweden. ann-marie.calender@rheuma.gu.se | lld:pubmed |
| pubmed-article:16697230 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16697230 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:17395 | entrezgene:pubmed | pubmed-article:16697230 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16697230 | lld:entrezgene |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16697230 | lld:pubmed |
