pubmed-article:16690916 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:16690916 | lifeskim:mentions | umls-concept:C0042216 | lld:lifeskim |
pubmed-article:16690916 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
pubmed-article:16690916 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
pubmed-article:16690916 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
pubmed-article:16690916 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
pubmed-article:16690916 | lifeskim:mentions | umls-concept:C0001721 | lld:lifeskim |
pubmed-article:16690916 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
pubmed-article:16690916 | lifeskim:mentions | umls-concept:C0150647 | lld:lifeskim |
pubmed-article:16690916 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
pubmed-article:16690916 | lifeskim:mentions | umls-concept:C0333467 | lld:lifeskim |
pubmed-article:16690916 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
pubmed-article:16690916 | pubmed:issue | Pt 6 | lld:pubmed |
pubmed-article:16690916 | pubmed:dateCreated | 2006-5-12 | lld:pubmed |
pubmed-article:16690916 | pubmed:abstractText | The vaccinia virus (VACV) protein A55 is a BTB/kelch protein with a broad-complex, tramtrack and bric-a-brac (BTB) domain in the N-terminal region and five kelch repeats in the C-terminal half. The BTB/kelch subgroup of the kelch superfamily of proteins has been associated with a wide variety of functions including regulation of the cytoskeleton. VACV contains three genes predicted to encode BTB/kelch proteins: A55R, F3L and C2L. The A55R gene product has been identified as an intracellular protein of 64 kDa that is expressed late in infection. A VACV strain lacking 93.6% of the A55R open reading frame (vdeltaA55) was constructed and found to have an unaltered growth rate in vivo but a different plaque morphology and cytopathic effect, as well as reduced development of VACV-induced Ca2+-independent cell/extracellular matrix adhesion. In a murine intradermal model of VACV infection, a virus lacking the A55R gene induced larger lesions than wild-type and revertant control viruses. | lld:pubmed |
pubmed-article:16690916 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:16690916 | pubmed:language | eng | lld:pubmed |
pubmed-article:16690916 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:16690916 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:16690916 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:16690916 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:16690916 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:16690916 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:16690916 | pubmed:month | Jun | lld:pubmed |
pubmed-article:16690916 | pubmed:issn | 0022-1317 | lld:pubmed |
pubmed-article:16690916 | pubmed:author | pubmed-author:SmithGeoffrey... | lld:pubmed |
pubmed-article:16690916 | pubmed:author | pubmed-author:BeardPhilippa... | lld:pubmed |
pubmed-article:16690916 | pubmed:author | pubmed-author:FroggattGraha... | lld:pubmed |
pubmed-article:16690916 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:16690916 | pubmed:volume | 87 | lld:pubmed |
pubmed-article:16690916 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:16690916 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:16690916 | pubmed:pagination | 1521-9 | lld:pubmed |
pubmed-article:16690916 | pubmed:dateRevised | 2007-8-13 | lld:pubmed |
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pubmed-article:16690916 | pubmed:meshHeading | pubmed-meshheading:16690916... | lld:pubmed |
pubmed-article:16690916 | pubmed:meshHeading | pubmed-meshheading:16690916... | lld:pubmed |
pubmed-article:16690916 | pubmed:meshHeading | pubmed-meshheading:16690916... | lld:pubmed |
pubmed-article:16690916 | pubmed:meshHeading | pubmed-meshheading:16690916... | lld:pubmed |
pubmed-article:16690916 | pubmed:year | 2006 | lld:pubmed |
pubmed-article:16690916 | pubmed:articleTitle | Vaccinia virus kelch protein A55 is a 64 kDa intracellular factor that affects virus-induced cytopathic effect and the outcome of infection in a murine intradermal model. | lld:pubmed |
pubmed-article:16690916 | pubmed:affiliation | Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place, London W2 1PG, UK. | lld:pubmed |
pubmed-article:16690916 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:16690916 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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