| pubmed-article:16687161 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16687161 | lifeskim:mentions | umls-concept:C1093046 | lld:lifeskim |
| pubmed-article:16687161 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:16687161 | lifeskim:mentions | umls-concept:C0042720 | lld:lifeskim |
| pubmed-article:16687161 | lifeskim:mentions | umls-concept:C1521871 | lld:lifeskim |
| pubmed-article:16687161 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:16687161 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16687161 | pubmed:dateCreated | 2006-7-31 | lld:pubmed |
| pubmed-article:16687161 | pubmed:abstractText | An abundant human papillomavirus (HPV) protein E1/\E4 is expressed late in the virus life cycle in the terminally differentiated layers of epithelia. The expression of E1/\E4 usually coincides with the onset of viral DNA amplification. However, the function of E1/\E4 in viral life cycle is not completely understood. To examine the role of E1/\E4 in the virus life cycle, we introduced a single nucleotide change in the HPV-11 genome to result in a truncation of E1/\E4 protein without affecting the E2 amino acid sequence. This mutated HPV-11 genome was introduced into a human foreskin keratinocyte cell line immortalized by the catalytic subunit of human telomerase, deficient in p16(INK4a) expression, and previously shown to support the HPV-11 life cycle when grown in organotypic raft culture. We have demonstrated that E1/\E4 is dispensable for HPV-11 viral DNA amplification in the late stages of the viral life cycle. | lld:pubmed |
| pubmed-article:16687161 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16687161 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16687161 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16687161 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16687161 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16687161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16687161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16687161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16687161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16687161 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16687161 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16687161 | pubmed:issn | 0042-6822 | lld:pubmed |
| pubmed-article:16687161 | pubmed:author | pubmed-author:FandII | lld:pubmed |
| pubmed-article:16687161 | pubmed:author | pubmed-author:HowettM KMK | lld:pubmed |
| pubmed-article:16687161 | pubmed:author | pubmed-author:DoorbarJJ | lld:pubmed |
| pubmed-article:16687161 | pubmed:author | pubmed-author:BudgeonL RLR | lld:pubmed |
| pubmed-article:16687161 | pubmed:author | pubmed-author:BriggsE RER | lld:pubmed |
| pubmed-article:16687161 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16687161 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16687161 | pubmed:volume | 351 | lld:pubmed |
| pubmed-article:16687161 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16687161 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16687161 | pubmed:pagination | 271-9 | lld:pubmed |
| pubmed-article:16687161 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:16687161 | pubmed:meshHeading | pubmed-meshheading:16687161... | lld:pubmed |
| pubmed-article:16687161 | pubmed:meshHeading | pubmed-meshheading:16687161... | lld:pubmed |
| pubmed-article:16687161 | pubmed:meshHeading | pubmed-meshheading:16687161... | lld:pubmed |
| pubmed-article:16687161 | pubmed:meshHeading | pubmed-meshheading:16687161... | lld:pubmed |
| pubmed-article:16687161 | pubmed:meshHeading | pubmed-meshheading:16687161... | lld:pubmed |
| pubmed-article:16687161 | pubmed:meshHeading | pubmed-meshheading:16687161... | lld:pubmed |
| pubmed-article:16687161 | pubmed:meshHeading | pubmed-meshheading:16687161... | lld:pubmed |
| pubmed-article:16687161 | pubmed:meshHeading | pubmed-meshheading:16687161... | lld:pubmed |
| pubmed-article:16687161 | pubmed:meshHeading | pubmed-meshheading:16687161... | lld:pubmed |
| pubmed-article:16687161 | pubmed:meshHeading | pubmed-meshheading:16687161... | lld:pubmed |
| pubmed-article:16687161 | pubmed:meshHeading | pubmed-meshheading:16687161... | lld:pubmed |
| pubmed-article:16687161 | pubmed:meshHeading | pubmed-meshheading:16687161... | lld:pubmed |
| pubmed-article:16687161 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16687161 | pubmed:articleTitle | The human papillomavirus type 11 E1/\E4 protein is not essential for viral genome amplification. | lld:pubmed |
| pubmed-article:16687161 | pubmed:affiliation | Department of Bioscience and Biotechnology, Drexel University, Stratton Hall Rm. 118, 3141 Chestnut Street, Philadelphia, PA 19104, USA. | lld:pubmed |
| pubmed-article:16687161 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16687161 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16687161 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16687161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16687161 | lld:pubmed |
