| pubmed-article:16685441 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16685441 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:16685441 | lifeskim:mentions | umls-concept:C0003123 | lld:lifeskim |
| pubmed-article:16685441 | lifeskim:mentions | umls-concept:C0006625 | lld:lifeskim |
| pubmed-article:16685441 | lifeskim:mentions | umls-concept:C0911014 | lld:lifeskim |
| pubmed-article:16685441 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:16685441 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:16685441 | pubmed:dateCreated | 2006-5-10 | lld:pubmed |
| pubmed-article:16685441 | pubmed:abstractText | Ghrelin is a novel brain-gut peptide that stimulates food intake and may secondarily increase body weight via a growth hormone secretagogue receptor (GHS-R). Tumor-bearing mice (MCG101), characterized by anorexia, fat loss and muscle wasting due to increased concentration of PGE2 and proinflammatory cytokines (IL-1beta, IL-6, TNF-alpha), were provided ghrelin i.p. at a low (20 microg/day) and high dose (40 microg/day) to examine the ability of ghrelin to counteract tumor-induced anorexia. Immunohistochemical staining and Western blot analyses were used to identify GHS-R expression in the brain as well as its relationship to NPY expression in hypothalamic neurons. GHS-R mRNA in hypothalamus and ghrelin mRNA in gastric fundus were quantified by RT-PCR. Body composition was determined by carcass extractions. GHS-R expression in hypothalamus and plasma ghrelin levels were significantly increased in freely-fed tumor-bearing mice, while gastric fundus expression of ghrelin was unaltered compared to non-tumor-bearing mice (controls). Ghrelin treatment increased food intake, body weight and whole body fat at both low and high doses of ghrelin in normal controls, while tumor-bearing mice showed improved intake and body composition at the high dose of ghrelin only. Exogenous ghrelin normalized the GHS-R expression in hypothalamus from tumor-bearing mice without alterations in the gastric fundus expression of ghrelin. Tumor growth was not altered by exogenous ghrelin. Our results indicate that MCG 101-bearing mice became ghrelin resistant despite upregulation of hypothalamic GHS-R expression, which confirms similar indirect observations in cancer patients. Thus, other factors downstream of the ghrelin-GHS-R system appear to be more important than ghrelin to explain cancer-induced anorexia. | lld:pubmed |
| pubmed-article:16685441 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16685441 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16685441 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16685441 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16685441 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16685441 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16685441 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16685441 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16685441 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16685441 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16685441 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16685441 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16685441 | pubmed:issn | 1019-6439 | lld:pubmed |
| pubmed-article:16685441 | pubmed:author | pubmed-author:WangWenhuaW | lld:pubmed |
| pubmed-article:16685441 | pubmed:author | pubmed-author:LönnrothChris... | lld:pubmed |
| pubmed-article:16685441 | pubmed:author | pubmed-author:LundholmKentK | lld:pubmed |
| pubmed-article:16685441 | pubmed:author | pubmed-author:AnderssonMari... | lld:pubmed |
| pubmed-article:16685441 | pubmed:author | pubmed-author:IresjöBritt-M... | lld:pubmed |
| pubmed-article:16685441 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16685441 | pubmed:volume | 28 | lld:pubmed |
| pubmed-article:16685441 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16685441 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16685441 | pubmed:pagination | 1393-400 | lld:pubmed |
| pubmed-article:16685441 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:16685441 | pubmed:meshHeading | pubmed-meshheading:16685441... | lld:pubmed |
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| pubmed-article:16685441 | pubmed:meshHeading | pubmed-meshheading:16685441... | lld:pubmed |
| pubmed-article:16685441 | pubmed:meshHeading | pubmed-meshheading:16685441... | lld:pubmed |
| pubmed-article:16685441 | pubmed:meshHeading | pubmed-meshheading:16685441... | lld:pubmed |
| pubmed-article:16685441 | pubmed:meshHeading | pubmed-meshheading:16685441... | lld:pubmed |
| pubmed-article:16685441 | pubmed:meshHeading | pubmed-meshheading:16685441... | lld:pubmed |
| pubmed-article:16685441 | pubmed:meshHeading | pubmed-meshheading:16685441... | lld:pubmed |
| pubmed-article:16685441 | pubmed:meshHeading | pubmed-meshheading:16685441... | lld:pubmed |
| pubmed-article:16685441 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16685441 | pubmed:articleTitle | Effects of ghrelin on anorexia in tumor-bearing mice with eicosanoid-related cachexia. | lld:pubmed |
| pubmed-article:16685441 | pubmed:affiliation | Surgical Metabolic Research Laboratory at Lundberg Laboratory for Cancer Research, Department of Surgery, Sahlgrenska University Hospital, Göteborg University, Göteborg, Sweden. | lld:pubmed |
| pubmed-article:16685441 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16685441 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16685441 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16685441 | lld:pubmed |
