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pubmed-article:16684266pubmed:abstractTextAmoxicillin-based therapies are highly effective for the treatment of Helicobacter pylori infections, but the efficacy may decrease as the incidence of amoxicillin resistance is increasing. So far, the molecular mechanism underlying stable amoxicillin resistance has only been identified for a few naturally occurring amoxicillin-resistant (Amx) H. pylori isolates, and is mediated by mutations in penicillin-binding protein 1A (PBP1A). In this study the molecular mechanism underlying amoxicillin resistance of seven additional Amx H. pylori isolates has been established.lld:pubmed
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pubmed-article:16684266pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:16684266pubmed:articleTitleMultiple mutations in or adjacent to the conserved penicillin-binding protein motifs of the penicillin-binding protein 1A confer amoxicillin resistance to Helicobacter pylori.lld:pubmed
pubmed-article:16684266pubmed:affiliationDepartment of Gastroenterology and Hepatology, Erasmus MC - University Medical Center, Rotterdam, The Netherlands.lld:pubmed
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pubmed-article:16684266pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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