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pubmed-article:16684145pubmed:dateCreated2006-5-10lld:pubmed
pubmed-article:16684145pubmed:abstractTextOne hundred and fifty piglets were randomly allotted to one of six treatments to determine the effects of olaquindox and cyadox on growth and intestinal immune response including the number of intraepithelial lymphocytes and immunoglobulin A secreting cells (ASCs) during the three-week period. A 2 x 3 factorial arrangement of treatments was employed with the following factors: (1) Escherichia coli (O(139):K(88), 10(10) CFU) inoculation or control and (2) no antimicrobials, 100 mg/kg olaquindox and 100 mg/kg cyadox in the basal diet respectively. The antimicrobial supplementations improved (p < 0.01) average daily gain and feed conversion ratio (FCR) during the experiment. Average daily gain and FCR in the cyadox-supplemented pigs were higher (p < 0.05) than those in the olaquindox-supplemented pigs. Intraepithelial lymphocytes and ASCs decreased (p < 0.05) when the diets were supplemented. Jejunal ASCs in the cyadox-supplemented pigs were lower (p < 0.05) than those in the olaquindox-supplemented pigs. Olaquindox and cyadox suppressed E. coli-induced intestinal immune activation, which may be involved in the observed growth promotion.lld:pubmed
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pubmed-article:16684145pubmed:authorpubmed-author:WangY LYLlld:pubmed
pubmed-article:16684145pubmed:authorpubmed-author:YuanZ HZHlld:pubmed
pubmed-article:16684145pubmed:authorpubmed-author:FanS XSXlld:pubmed
pubmed-article:16684145pubmed:authorpubmed-author:DingM XMXlld:pubmed
pubmed-article:16684145pubmed:authorpubmed-author:ZhuH LHLlld:pubmed
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pubmed-article:16684145pubmed:volume90lld:pubmed
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pubmed-article:16684145pubmed:pagination238-43lld:pubmed
pubmed-article:16684145pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:16684145pubmed:year2006lld:pubmed
pubmed-article:16684145pubmed:articleTitleOlaquindox and cyadox stimulate growth and decrease intestinal mucosal immunity of piglets orally inoculated with Escherichia coli.lld:pubmed
pubmed-article:16684145pubmed:affiliationNational Reference Laboratory of Veterinary Drug Residues/MOA Key Laboratory of Food Safety Evaluation, Huazhong Agricultural University, Wuhan, Hubei, China.lld:pubmed
pubmed-article:16684145pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16684145pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed