| pubmed-article:16682957 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16682957 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:16682957 | lifeskim:mentions | umls-concept:C0080055 | lld:lifeskim |
| pubmed-article:16682957 | lifeskim:mentions | umls-concept:C0387583 | lld:lifeskim |
| pubmed-article:16682957 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
| pubmed-article:16682957 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:16682957 | pubmed:issue | 42 | lld:pubmed |
| pubmed-article:16682957 | pubmed:dateCreated | 2006-9-21 | lld:pubmed |
| pubmed-article:16682957 | pubmed:abstractText | Overexpression of cyclooxygenase-2 (Cox-2) is thought to exert antiapoptotic effects in cancer. Here we show that the tumor suppressor p53 upregulated Cox-2 in esophageal and colon cancer cell lines by inducing the binding of nuclear factor-kappaB (NF-kappaB) to its response element in the COX-2 promoter. Inhibition of NF-kappaB prevented p53 induction of Cox-2 expression. Cooperation between p53 and NF-kappaB was required for activation of COX-2 promoter in response to daunomycin, a DNA-damaging agent. Pharmacological inhibition of Cox-2 enhanced apoptosis in response to daunomycin, in particular in cells containing active p53. In esophageal cancer, there was a correlation between Cox-2 expression and wild-type TP53 in Barrett's esophagus (BE) and in adenocarcinoma, but not in squamous cell carcinoma (P<0.01). These results suggest that p53 and NF-kappaB cooperate in upregulating Cox-2 expression, promoting cell survival in inflammatory precursor lesions such as BE. | lld:pubmed |
| pubmed-article:16682957 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16682957 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16682957 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16682957 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16682957 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16682957 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16682957 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16682957 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:16682957 | pubmed:author | pubmed-author:BenoitVV | lld:pubmed |
| pubmed-article:16682957 | pubmed:author | pubmed-author:HautefeuilleA... | lld:pubmed |
| pubmed-article:16682957 | pubmed:author | pubmed-author:HainautPP | lld:pubmed |
| pubmed-article:16682957 | pubmed:author | pubmed-author:BoursVV | lld:pubmed |
| pubmed-article:16682957 | pubmed:author | pubmed-author:de Moura... | lld:pubmed |
| pubmed-article:16682957 | pubmed:author | pubmed-author:GOWR CRC | lld:pubmed |
| pubmed-article:16682957 | pubmed:author | pubmed-author:ChariotAA | lld:pubmed |
| pubmed-article:16682957 | pubmed:author | pubmed-author:TanièrePP | lld:pubmed |
| pubmed-article:16682957 | pubmed:author | pubmed-author:ScoazecJ-YJY | lld:pubmed |
| pubmed-article:16682957 | pubmed:author | pubmed-author:MervilleM-PMP | lld:pubmed |
| pubmed-article:16682957 | pubmed:author | pubmed-author:TaranchonEE | lld:pubmed |
| pubmed-article:16682957 | pubmed:author | pubmed-author:de MoraesEE | lld:pubmed |
| pubmed-article:16682957 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16682957 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:16682957 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:16682957 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16682957 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16682957 | pubmed:pagination | 5708-18 | lld:pubmed |
| pubmed-article:16682957 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:16682957 | pubmed:meshHeading | pubmed-meshheading:16682957... | lld:pubmed |
| pubmed-article:16682957 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16682957 | pubmed:articleTitle | Transcriptional activation of cyclooxygenase-2 by tumor suppressor p53 requires nuclear factor-kappaB. | lld:pubmed |
| pubmed-article:16682957 | pubmed:affiliation | Laboratory of Medical Chemistry and Human Genetics, Center for Biomedical Integrated Genoproteomics, University of Liège, Liège, Belgium. | lld:pubmed |
| pubmed-article:16682957 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16682957 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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