| pubmed-article:16680149 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16680149 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:16680149 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:16680149 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:16680149 | lifeskim:mentions | umls-concept:C0443211 | lld:lifeskim |
| pubmed-article:16680149 | lifeskim:mentions | umls-concept:C0205195 | lld:lifeskim |
| pubmed-article:16680149 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:16680149 | pubmed:dateCreated | 2006-6-8 | lld:pubmed |
| pubmed-article:16680149 | pubmed:abstractText | Tumor-cell apoptosis is the basis of many cancer therapies, and tumor-specific T cells are the principal effectors of successful antitumor immunotherapies. Here we show that induction of tumor-cell apoptosis by an agonistic monoclonal antibody to DR5, the apoptosis-inducing receptor for TNF-related apoptosis-inducing ligand (TRAIL), combined with T-cell activation by agonistic monoclonal antibodies to the costimulatory molecules CD40 and CD137, potently and rapidly stimulated tumor-specific effector CD8+ T cells capable of eradicating preestablished tumors. Primary fibrosarcomas initiated with the carcinogen 3-methylcholanthrene (MCA), multiorgan metastases and a primary tumor containing as many as 90% tumor cells resistant to DR5-specific monoclonal antibody were rejected without apparent toxicity or induction of autoimmunity. This combination therapy of three monoclonal antibodies (trimAb) rapidly induced tumor-specific CD8+ T cells producing interferon (IFN)-gamma in the tumor-draining lymph node, consistent with a crucial requirement for CD8+ T cells and IFN-gamma in the tumor rejection process. These results in mice indicate that a rational monoclonal antibody-based therapy that both causes tumor-cell apoptosis through DR5 and activates T cells may be an effective strategy for cancer immunotherapy in humans. | lld:pubmed |
| pubmed-article:16680149 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16680149 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16680149 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16680149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16680149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16680149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16680149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16680149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16680149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16680149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16680149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16680149 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16680149 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16680149 | pubmed:issn | 1078-8956 | lld:pubmed |
| pubmed-article:16680149 | pubmed:author | pubmed-author:TakedaKazuyos... | lld:pubmed |
| pubmed-article:16680149 | pubmed:author | pubmed-author:YagitaHideoH | lld:pubmed |
| pubmed-article:16680149 | pubmed:author | pubmed-author:SmythMark JMJ | lld:pubmed |
| pubmed-article:16680149 | pubmed:author | pubmed-author:KojimaYukoY | lld:pubmed |
| pubmed-article:16680149 | pubmed:author | pubmed-author:OkumuraKoK | lld:pubmed |
| pubmed-article:16680149 | pubmed:author | pubmed-author:GejyoFumitake... | lld:pubmed |
| pubmed-article:16680149 | pubmed:author | pubmed-author:AkibaHisayaH | lld:pubmed |
| pubmed-article:16680149 | pubmed:author | pubmed-author:MittlerRobert... | lld:pubmed |
| pubmed-article:16680149 | pubmed:author | pubmed-author:YoshizawaHiro... | lld:pubmed |
| pubmed-article:16680149 | pubmed:author | pubmed-author:UnoTomoyasuT | lld:pubmed |
| pubmed-article:16680149 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16680149 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:16680149 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16680149 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16680149 | pubmed:pagination | 693-8 | lld:pubmed |
| pubmed-article:16680149 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:16680149 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16680149 | pubmed:articleTitle | Eradication of established tumors in mice by a combination antibody-based therapy. | lld:pubmed |
| pubmed-article:16680149 | pubmed:affiliation | Department of Immunology, Juntendo University School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo 113-8421, Japan. | lld:pubmed |
| pubmed-article:16680149 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16680149 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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