| pubmed-article:16676069 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16676069 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:16676069 | lifeskim:mentions | umls-concept:C0027883 | lld:lifeskim |
| pubmed-article:16676069 | lifeskim:mentions | umls-concept:C0160390 | lld:lifeskim |
| pubmed-article:16676069 | lifeskim:mentions | umls-concept:C0003440 | lld:lifeskim |
| pubmed-article:16676069 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:16676069 | lifeskim:mentions | umls-concept:C1999177 | lld:lifeskim |
| pubmed-article:16676069 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:16676069 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:16676069 | pubmed:dateCreated | 2006-5-5 | lld:pubmed |
| pubmed-article:16676069 | pubmed:abstractText | We recently demonstrated that antithrombin (AT) reduces ischemia/reperfusion (I/R)-induced liver injury in rats by increasing hepatic tissue levels of calcitonin gene-related peptide (CGRP), a neuropeptide released from the sensory nerve endings. In the present study, we examined the effect of AT on I/R-induced liver injury in wild type mice (CGRP+/+) and congenitally alphaCGRP-deficient mice (CGRP-/-). We also investigated any effects of AT on CGRP release from dorsal root ganglion neurons (DRG) isolated from CGRP+/+. Based on results obtained in the present study, we attempted to determine if the anti-inflammatory activity of AT in vivo is dependent mainly on sensory neuron activation. AT enhanced ischemia/reperfusion-induced increases in hepatic tissue levels of CGRP and 6-keto-PGF(1alpha), a stable metabolite of PGI2, in CGRP+/+, but it did not enhance these increases in CGRP-/-. AT inhibited reperfusion-induced increases in serum alanine aminotransferase levels by increasing hepatic tissue blood flow and by attenuating increases in hepatic levels of tumor necrosis factor and myeloperoxidase in CGRP+/+, although it showed neither of these therapeutic effects in CGRP-/-. AT increased CGRP release from cultured DRGs only in the presence of anandamide, and AT-induced increase in CGRP release was not observed in the presence KT5720, an inhibitor of protein kinase A (PKA). AT markedly increased intracellular levels of cAMP in the presence of anandamide. These results strongly suggest that AT might reduce I/R-induced liver injury by enhancing activation of the sensory neurons through activation of PKA in sensory neurons. | lld:pubmed |
| pubmed-article:16676069 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16676069 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16676069 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16676069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16676069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16676069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16676069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16676069 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16676069 | pubmed:month | May | lld:pubmed |
| pubmed-article:16676069 | pubmed:issn | 0340-6245 | lld:pubmed |
| pubmed-article:16676069 | pubmed:author | pubmed-author:OkajimaKenjiK | lld:pubmed |
| pubmed-article:16676069 | pubmed:author | pubmed-author:UchibaMitsuhi... | lld:pubmed |
| pubmed-article:16676069 | pubmed:author | pubmed-author:HaradaNaoakiN | lld:pubmed |
| pubmed-article:16676069 | pubmed:author | pubmed-author:NakagataNaomi... | lld:pubmed |
| pubmed-article:16676069 | pubmed:author | pubmed-author:KuriharaHirok... | lld:pubmed |
| pubmed-article:16676069 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16676069 | pubmed:volume | 95 | lld:pubmed |
| pubmed-article:16676069 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16676069 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16676069 | pubmed:pagination | 788-95 | lld:pubmed |
| pubmed-article:16676069 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:16676069 | pubmed:meshHeading | pubmed-meshheading:16676069... | lld:pubmed |
| pubmed-article:16676069 | pubmed:meshHeading | pubmed-meshheading:16676069... | lld:pubmed |
| pubmed-article:16676069 | pubmed:meshHeading | pubmed-meshheading:16676069... | lld:pubmed |
| pubmed-article:16676069 | pubmed:meshHeading | pubmed-meshheading:16676069... | lld:pubmed |
| pubmed-article:16676069 | pubmed:meshHeading | pubmed-meshheading:16676069... | lld:pubmed |
| pubmed-article:16676069 | pubmed:meshHeading | pubmed-meshheading:16676069... | lld:pubmed |
| pubmed-article:16676069 | pubmed:meshHeading | pubmed-meshheading:16676069... | lld:pubmed |
| pubmed-article:16676069 | pubmed:meshHeading | pubmed-meshheading:16676069... | lld:pubmed |
| pubmed-article:16676069 | pubmed:meshHeading | pubmed-meshheading:16676069... | lld:pubmed |
| pubmed-article:16676069 | pubmed:meshHeading | pubmed-meshheading:16676069... | lld:pubmed |
| pubmed-article:16676069 | pubmed:meshHeading | pubmed-meshheading:16676069... | lld:pubmed |
| pubmed-article:16676069 | pubmed:meshHeading | pubmed-meshheading:16676069... | lld:pubmed |
| pubmed-article:16676069 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16676069 | pubmed:articleTitle | Antithrombin reduces reperfusion-induced liver injury in mice by enhancing sensory neuron activation. | lld:pubmed |
| pubmed-article:16676069 | pubmed:affiliation | Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto, Japan. | lld:pubmed |
| pubmed-article:16676069 | pubmed:publicationType | Journal Article | lld:pubmed |
