| pubmed-article:16648854 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16648854 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:16648854 | lifeskim:mentions | umls-concept:C1167250 | lld:lifeskim |
| pubmed-article:16648854 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:16648854 | lifeskim:mentions | umls-concept:C0059973 | lld:lifeskim |
| pubmed-article:16648854 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:16648854 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:16648854 | lifeskim:mentions | umls-concept:C0392762 | lld:lifeskim |
| pubmed-article:16648854 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:16648854 | pubmed:dateCreated | 2006-5-22 | lld:pubmed |
| pubmed-article:16648854 | pubmed:abstractText | Ligation of the B cell antigen receptor (BCR) with antigen induces lipid raft coalescence, a process that occurs after crosslinking of a variety of signaling receptors and is thought to potentiate cellular activation. To investigate lipid raft dynamics during BCR signaling, we quantitatively analyzed the B cell lipid raft proteome. BCR engagement induced dissociation of the adaptor protein ezrin from lipid rafts as well as threonine dephosphorylation of ezrin and its concomitant detachment from actin, indicating a transient uncoupling of lipid rafts from the actin cytoskeleton. Expression of constitutively active ezrin chimeras inhibited the BCR-induced coalescence of lipid rafts. Our data demonstrate that the release of ezrin from lipid rafts acts as a critical trigger that regulates lipid raft dynamics during BCR signaling. | lld:pubmed |
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| pubmed-article:16648854 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16648854 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16648854 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16648854 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16648854 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16648854 | pubmed:issn | 1529-2908 | lld:pubmed |
| pubmed-article:16648854 | pubmed:author | pubmed-author:AebersoldRued... | lld:pubmed |
| pubmed-article:16648854 | pubmed:author | pubmed-author:WattsJulian... | lld:pubmed |
| pubmed-article:16648854 | pubmed:author | pubmed-author:DeFrancoAntho... | lld:pubmed |
| pubmed-article:16648854 | pubmed:author | pubmed-author:GuptaNeetuN | lld:pubmed |
| pubmed-article:16648854 | pubmed:author | pubmed-author:WollscheidBer... | lld:pubmed |
| pubmed-article:16648854 | pubmed:author | pubmed-author:ScheerBarbara... | lld:pubmed |
| pubmed-article:16648854 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16648854 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:16648854 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16648854 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16648854 | pubmed:pagination | 625-33 | lld:pubmed |
| pubmed-article:16648854 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:16648854 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16648854 | pubmed:articleTitle | Quantitative proteomic analysis of B cell lipid rafts reveals that ezrin regulates antigen receptor-mediated lipid raft dynamics. | lld:pubmed |
| pubmed-article:16648854 | pubmed:affiliation | Department of Microbiology and Immunology, University of California, San Francisco, California 94143, USA. | lld:pubmed |
| pubmed-article:16648854 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16648854 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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