An adverse fetal environment may permanently modify the effects of specific genes on glucose tolerance, insulin secretion, and insulin sensitivity. In the present study, we assessed a possible interaction of the peroxisome proliferator-activated receptor (PPAR)-gamma2 Pro12Ala polymorphism with prenatal exposure to famine on glucose and insulin metabolism.
The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 gene on glucose/insulin metabolism interact with prenatal exposure to famine.
Academic Medical Centre, Department of Clinical Epidemiology and Biostatistics, Room nr J1B-210-1, Meibergdreef 9, P.O. Box 22660, 1100 DD, Amsterdam, Netherlands. s.r.derooij@amc.uva.nl
