| pubmed-article:16640648 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16640648 | lifeskim:mentions | umls-concept:C0002395 | lld:lifeskim |
| pubmed-article:16640648 | lifeskim:mentions | umls-concept:C0162783 | lld:lifeskim |
| pubmed-article:16640648 | lifeskim:mentions | umls-concept:C0011570 | lld:lifeskim |
| pubmed-article:16640648 | lifeskim:mentions | umls-concept:C0170657 | lld:lifeskim |
| pubmed-article:16640648 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:16640648 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16640648 | pubmed:dateCreated | 2006-4-27 | lld:pubmed |
| pubmed-article:16640648 | pubmed:abstractText | Previous studies investigating the serotonin transporter (SERT) in depression have been inconsistent and included a large proportion of subjects who had committed suicide. In Alzheimer's disease studies have generally reported a reduction in SERT density but have not compared Alzheimer's disease subjects with and without comorbid major depression. We conducted a post mortem study of SERT density in the prefrontal cortex in normal elderly, a group of elderly depressed subjects and in Alzheimer's disease subjects with and without major depression. A post mortem study comparing SERT density in the prefrontal cortex in elderly controls (n = 10), subjects with major depression (n = 8) and subjects with Alzheimer's disease with (n = 9) and without (n = 5) comorbid major depression. We used autoradiography to measure the density of [3H]CN-IMI binding (non-specific binding determined with citalopram) to the SERT in the prefrontal cortex. We found a marked reduction in specific SERT binding in the prefrontal cortex in Alzheimer's disease subjects compared with both control (P = 0.002) and depressed subjects (P = 0.004) but no difference in SERT binding between depressed and control subjects or between Alzheimer's disease subjects with and without depression. Our study confirms previous reports of a reduction in SERT binding in Alzheimer's disease but indicates this reduction is not greater in Alzheimer's disease subjects who also have had major depression. In a group of subjects more typical of late-life depression we did not identify any alterations in SERT density. | lld:pubmed |
| pubmed-article:16640648 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16640648 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16640648 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16640648 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16640648 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16640648 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16640648 | pubmed:issn | 0305-1846 | lld:pubmed |
| pubmed-article:16640648 | pubmed:author | pubmed-author:PerryEE | lld:pubmed |
| pubmed-article:16640648 | pubmed:author | pubmed-author:FerrierI NIN | lld:pubmed |
| pubmed-article:16640648 | pubmed:author | pubmed-author:ThomasA JAJ | lld:pubmed |
| pubmed-article:16640648 | pubmed:author | pubmed-author:O'BrienJ TJT | lld:pubmed |
| pubmed-article:16640648 | pubmed:author | pubmed-author:IncePP | lld:pubmed |
| pubmed-article:16640648 | pubmed:author | pubmed-author:PiggottMM | lld:pubmed |
| pubmed-article:16640648 | pubmed:author | pubmed-author:HendriksenMM | lld:pubmed |
| pubmed-article:16640648 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16640648 | pubmed:volume | 32 | lld:pubmed |
| pubmed-article:16640648 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16640648 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16640648 | pubmed:pagination | 296-303 | lld:pubmed |
| pubmed-article:16640648 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:16640648 | pubmed:meshHeading | pubmed-meshheading:16640648... | lld:pubmed |
| pubmed-article:16640648 | pubmed:meshHeading | pubmed-meshheading:16640648... | lld:pubmed |
| pubmed-article:16640648 | pubmed:meshHeading | pubmed-meshheading:16640648... | lld:pubmed |
| pubmed-article:16640648 | pubmed:meshHeading | pubmed-meshheading:16640648... | lld:pubmed |
| pubmed-article:16640648 | pubmed:meshHeading | pubmed-meshheading:16640648... | lld:pubmed |
| pubmed-article:16640648 | pubmed:meshHeading | pubmed-meshheading:16640648... | lld:pubmed |
| pubmed-article:16640648 | pubmed:meshHeading | pubmed-meshheading:16640648... | lld:pubmed |
| pubmed-article:16640648 | pubmed:meshHeading | pubmed-meshheading:16640648... | lld:pubmed |
| pubmed-article:16640648 | pubmed:meshHeading | pubmed-meshheading:16640648... | lld:pubmed |
| pubmed-article:16640648 | pubmed:meshHeading | pubmed-meshheading:16640648... | lld:pubmed |
| pubmed-article:16640648 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16640648 | pubmed:articleTitle | A study of the serotonin transporter in the prefrontal cortex in late-life depression and Alzheimer's disease with and without depression. | lld:pubmed |
| pubmed-article:16640648 | pubmed:affiliation | School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Newcastle upon Tyne, UK. a.j.thomas@ncl.ac.uk | lld:pubmed |
| pubmed-article:16640648 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16640648 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:16640648 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16640648 | lld:pubmed |
