| pubmed-article:16638803 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16638803 | lifeskim:mentions | umls-concept:C0043457 | lld:lifeskim |
| pubmed-article:16638803 | lifeskim:mentions | umls-concept:C0231048 | lld:lifeskim |
| pubmed-article:16638803 | lifeskim:mentions | umls-concept:C0284555 | lld:lifeskim |
| pubmed-article:16638803 | lifeskim:mentions | umls-concept:C1519628 | lld:lifeskim |
| pubmed-article:16638803 | pubmed:issue | Pt 10 | lld:pubmed |
| pubmed-article:16638803 | pubmed:dateCreated | 2006-5-11 | lld:pubmed |
| pubmed-article:16638803 | pubmed:abstractText | Megalin/LRP2 is an endocytic receptor in the proximal tubules of the mammalian kidney that plays a central role in the clearance of metabolites from the glomerular filtrate. To establish a genetic model system for elucidation of molecular components of this retrieval pathway, we characterized orthologous transport processes in the zebrafish. We show that expression of megalin/LRP2 and its co-receptor cubilin is conserved in the larval zebrafish pronephros and demarcates a segment of the pronephric duct that is active in clearance of tracer from the ultrafiltrate. Knock-down of megalin/LRP2 causes lack of Rab4-positive endosomes in the proximal pronephric duct epithelium and abrogates apical endocytosis. Similarly, knock-down of the megalin/LRP2 adaptor Disabled 2 also blocks renal clearance processes. These results demonstrate the conservation of the megalin/LRP2 retrieval pathway between the larval zebrafish pronephros and the mammalian kidney and set the stage for dissection of the renal endocytic machinery in a simple model organism. Using this model system, we provide first genetic evidence that renal tubular endocytosis and formation of endosomes is a ligand-induced process that crucially depends on megalin/LRP2 activity. | lld:pubmed |
| pubmed-article:16638803 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16638803 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16638803 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16638803 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16638803 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16638803 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16638803 | pubmed:month | May | lld:pubmed |
| pubmed-article:16638803 | pubmed:issn | 0021-9533 | lld:pubmed |
| pubmed-article:16638803 | pubmed:author | pubmed-author:WillnowThomas... | lld:pubmed |
| pubmed-article:16638803 | pubmed:author | pubmed-author:DehmelBastian... | lld:pubmed |
| pubmed-article:16638803 | pubmed:author | pubmed-author:Abdelilah-Sey... | lld:pubmed |
| pubmed-article:16638803 | pubmed:author | pubmed-author:Bit-AvragimNa... | lld:pubmed |
| pubmed-article:16638803 | pubmed:author | pubmed-author:AnzenbergerUw... | lld:pubmed |
| pubmed-article:16638803 | pubmed:author | pubmed-author:RohrStefanS | lld:pubmed |
| pubmed-article:16638803 | pubmed:author | pubmed-author:RudolphFranzi... | lld:pubmed |
| pubmed-article:16638803 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16638803 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16638803 | pubmed:volume | 119 | lld:pubmed |
| pubmed-article:16638803 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16638803 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16638803 | pubmed:pagination | 2127-37 | lld:pubmed |
| pubmed-article:16638803 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:16638803 | pubmed:meshHeading | pubmed-meshheading:16638803... | lld:pubmed |
| pubmed-article:16638803 | pubmed:meshHeading | pubmed-meshheading:16638803... | lld:pubmed |
| pubmed-article:16638803 | pubmed:meshHeading | pubmed-meshheading:16638803... | lld:pubmed |
| pubmed-article:16638803 | pubmed:meshHeading | pubmed-meshheading:16638803... | lld:pubmed |
| pubmed-article:16638803 | pubmed:meshHeading | pubmed-meshheading:16638803... | lld:pubmed |
| pubmed-article:16638803 | pubmed:meshHeading | pubmed-meshheading:16638803... | lld:pubmed |
| pubmed-article:16638803 | pubmed:meshHeading | pubmed-meshheading:16638803... | lld:pubmed |
| pubmed-article:16638803 | pubmed:meshHeading | pubmed-meshheading:16638803... | lld:pubmed |
| pubmed-article:16638803 | pubmed:meshHeading | pubmed-meshheading:16638803... | lld:pubmed |
| pubmed-article:16638803 | pubmed:meshHeading | pubmed-meshheading:16638803... | lld:pubmed |
| pubmed-article:16638803 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16638803 | pubmed:articleTitle | Elucidation of megalin/LRP2-dependent endocytic transport processes in the larval zebrafish pronephros. | lld:pubmed |
| pubmed-article:16638803 | pubmed:affiliation | Max Delbrueck Center (MDC) for Molecular Medicine, Robert-Roessle Str. 10, 13125 Berlin, Germany. | lld:pubmed |
| pubmed-article:16638803 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16638803 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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