| pubmed-article:1662763 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1662763 | lifeskim:mentions | umls-concept:C0023861 | lld:lifeskim |
| pubmed-article:1662763 | lifeskim:mentions | umls-concept:C1136170 | lld:lifeskim |
| pubmed-article:1662763 | lifeskim:mentions | umls-concept:C0079429 | lld:lifeskim |
| pubmed-article:1662763 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:1662763 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:1662763 | pubmed:dateCreated | 1992-2-19 | lld:pubmed |
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| pubmed-article:1662763 | pubmed:abstractText | Evidence for pleiotropic activation of virulence genes in Listeria monocytogenes is presented. A complementation study of a spontaneous prfA-deletion mutant and analysis of cassette and transposon insertion mutants showed that the gene prfA activates the transcription of four independent genes which code for a phosphatidyl-inositol-specific phospholipase C (gene plcA), listeriolysin O (gene hlyA), a metallo-protease (gene prtA) and a lecithinase (gene prtC). Transcription of prfA is not constitutive. During the growth phase, two peaks of prfA transcript accumulation were observed: the first was during exponential growth, and the second was at the beginning of the stationary phase. In addition, two prfA-specific transcripts of 2.2 kb and 1 kb are detected. Early in exponential growth, prfA is co-transcribed with plcA which lies upstream prfA, giving rise to the 2.2 kb plcA-prfA transcript. In late-exponential growth and at the beginning of the stationary phase, prfA transcripts of 1 kb are predominantly detected. Our results demonstrate that since prfA controls plcA transcription, it also regulates its own synthesis. | lld:pubmed |
| pubmed-article:1662763 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:1662763 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1662763 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1662763 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:1662763 | pubmed:issn | 0950-382X | lld:pubmed |
| pubmed-article:1662763 | pubmed:author | pubmed-author:MilonGG | lld:pubmed |
| pubmed-article:1662763 | pubmed:author | pubmed-author:CossartPP | lld:pubmed |
| pubmed-article:1662763 | pubmed:author | pubmed-author:MengaudJJ | lld:pubmed |
| pubmed-article:1662763 | pubmed:author | pubmed-author:Vazquez-Bolan... | lld:pubmed |
| pubmed-article:1662763 | pubmed:author | pubmed-author:DramsiSS | lld:pubmed |
| pubmed-article:1662763 | pubmed:author | pubmed-author:GouinEE | lld:pubmed |
| pubmed-article:1662763 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1662763 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:1662763 | pubmed:geneSymbol | prf | lld:pubmed |
| pubmed-article:1662763 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1662763 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1662763 | pubmed:pagination | 2273-83 | lld:pubmed |
| pubmed-article:1662763 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:1662763 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1662763 | pubmed:articleTitle | Pleiotropic control of Listeria monocytogenes virulence factors by a gene that is autoregulated. | lld:pubmed |
| pubmed-article:1662763 | pubmed:affiliation | Unité de Génie Microbiologique, Institut Pasteur, Paris, France. | lld:pubmed |
| pubmed-article:1662763 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1662763 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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