| pubmed-article:1662554 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1662554 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:1662554 | lifeskim:mentions | umls-concept:C0242275 | lld:lifeskim |
| pubmed-article:1662554 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:1662554 | lifeskim:mentions | umls-concept:C0596290 | lld:lifeskim |
| pubmed-article:1662554 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:1662554 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
| pubmed-article:1662554 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1662554 | pubmed:dateCreated | 1992-2-14 | lld:pubmed |
| pubmed-article:1662554 | pubmed:abstractText | We investigated the role of transforming growth factor beta 1 (TGF-beta 1) in growth regulation of the murine osteoblastic cell line, MC3T3-E1. We detected TGF-beta activity in the conditioned medium of MC3T3-E1 cells and its activity was increased by acid treatment of the bioassay system using CC1 64 cells. Northern blot analysis revealed the expression of TGF-beta 1 precursor messenger ribonucleic acid (mRNA). MC3T3-E1 cells possessed a single class of high affinity TGF-beta 1 receptor (2.8 x 10(4) sites per cell, Kd = 196 pM). Cross-linking studies revealed three specific TGF-beta receptors with molecular masses of 65, 95 and 280 kDa. Both TGF-beta and epidermal growth factor (EGF) stimulated [3H]-thymidine incorporation into cells. EGF decreased the number of TGF-beta receptor dose-dependently, and pretreatment of cells with 10 nM EGF attenuated cell growth by TGF-beta. All these data suggested that TGF-beta might be an autocrine growth factor in murine osteoblastic MC3T3-E1 cells and that EGF might modulate the growth of cells by down-regulating the TGF-beta receptor level. | lld:pubmed |
| pubmed-article:1662554 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1662554 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1662554 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1662554 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1662554 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1662554 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1662554 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1662554 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1662554 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1662554 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1662554 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1662554 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1662554 | pubmed:issn | 0169-6009 | lld:pubmed |
| pubmed-article:1662554 | pubmed:author | pubmed-author:FujitaYY | lld:pubmed |
| pubmed-article:1662554 | pubmed:author | pubmed-author:MiyakeAA | lld:pubmed |
| pubmed-article:1662554 | pubmed:author | pubmed-author:IkegamiHH | lld:pubmed |
| pubmed-article:1662554 | pubmed:author | pubmed-author:TanizawaOO | lld:pubmed |
| pubmed-article:1662554 | pubmed:author | pubmed-author:KurachiHH | lld:pubmed |
| pubmed-article:1662554 | pubmed:author | pubmed-author:TerakawaNN | lld:pubmed |
| pubmed-article:1662554 | pubmed:author | pubmed-author:SakataMM | lld:pubmed |
| pubmed-article:1662554 | pubmed:author | pubmed-author:JikiharaHH | lld:pubmed |
| pubmed-article:1662554 | pubmed:author | pubmed-author:MorishigeKK | lld:pubmed |
| pubmed-article:1662554 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1662554 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:1662554 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1662554 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1662554 | pubmed:pagination | 125-35 | lld:pubmed |
| pubmed-article:1662554 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:1662554 | pubmed:meshHeading | pubmed-meshheading:1662554-... | lld:pubmed |
| pubmed-article:1662554 | pubmed:meshHeading | pubmed-meshheading:1662554-... | lld:pubmed |
| pubmed-article:1662554 | pubmed:meshHeading | pubmed-meshheading:1662554-... | lld:pubmed |
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| pubmed-article:1662554 | pubmed:meshHeading | pubmed-meshheading:1662554-... | lld:pubmed |
| pubmed-article:1662554 | pubmed:meshHeading | pubmed-meshheading:1662554-... | lld:pubmed |
| pubmed-article:1662554 | pubmed:meshHeading | pubmed-meshheading:1662554-... | lld:pubmed |
| pubmed-article:1662554 | pubmed:meshHeading | pubmed-meshheading:1662554-... | lld:pubmed |
| pubmed-article:1662554 | pubmed:meshHeading | pubmed-meshheading:1662554-... | lld:pubmed |
| pubmed-article:1662554 | pubmed:meshHeading | pubmed-meshheading:1662554-... | lld:pubmed |
| pubmed-article:1662554 | pubmed:meshHeading | pubmed-meshheading:1662554-... | lld:pubmed |
| pubmed-article:1662554 | pubmed:meshHeading | pubmed-meshheading:1662554-... | lld:pubmed |
| pubmed-article:1662554 | pubmed:meshHeading | pubmed-meshheading:1662554-... | lld:pubmed |
| pubmed-article:1662554 | pubmed:meshHeading | pubmed-meshheading:1662554-... | lld:pubmed |
| pubmed-article:1662554 | pubmed:meshHeading | pubmed-meshheading:1662554-... | lld:pubmed |
| pubmed-article:1662554 | pubmed:meshHeading | pubmed-meshheading:1662554-... | lld:pubmed |
| pubmed-article:1662554 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1662554 | pubmed:articleTitle | Epidermal growth factor attenuates cell proliferation by down-regulating the transforming growth factor-beta receptor in the osteoblastic cell line MC3T3-E1. | lld:pubmed |
| pubmed-article:1662554 | pubmed:affiliation | Department of Obstetrics and Gynecology, Osaka University Medical School, Japan. | lld:pubmed |
| pubmed-article:1662554 | pubmed:publicationType | Journal Article | lld:pubmed |
