| pubmed-article:16625024 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16625024 | lifeskim:mentions | umls-concept:C0085756 | lld:lifeskim |
| pubmed-article:16625024 | lifeskim:mentions | umls-concept:C0023823 | lld:lifeskim |
| pubmed-article:16625024 | lifeskim:mentions | umls-concept:C0597336 | lld:lifeskim |
| pubmed-article:16625024 | lifeskim:mentions | umls-concept:C0030608 | lld:lifeskim |
| pubmed-article:16625024 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:16625024 | pubmed:dateCreated | 2006-6-29 | lld:pubmed |
| pubmed-article:16625024 | pubmed:abstractText | Genomic regions that influence LDL particle size in African Americans are not known. We performed family-based linkage analyses to identify genomic regions that influence LDL particle size and also exert pleiotropic effects on two closely related lipid traits, high density lipoprotein cholesterol (HDL-C) and triglycerides, in African Americans. Subjects (n = 1,318, 63.0 +/- 9.5 years, 70% women, 79% hypertensive) were ascertained through sibships with two or more individuals diagnosed with essential hypertension before age 60. LDL particle size was measured by polyacrylamide gel electrophoresis, and triglyceride levels were log-transformed to reduce skewness. Genotypes were measured at 366 microsatellite marker loci distributed across the 22 autosomes. Univariate and bivariate linkage analyses were performed using a variance components approach. LDL particle size was highly heritable (h(2) = 0.78) and significantly (P < 0.0001) genetically correlated with HDL-C (rho(G) = 0.32) and log triglycerides (rho(G) = -0.43). Significant evidence of linkage for LDL particle size was present on chromosome 19 [85.3 centimorgan (cM), log of the odds (LOD) = 3.07, P = 0.0001], and suggestive evidence of linkage was present on chromosome 12 (90.8 cM, LOD = 2.02, P = 0.0011). Bivariate linkage analyses revealed tentative evidence for a region with pleiotropic effects on LDL particle size and HDL-C on chromosome 4 (52.9 cM, LOD = 2.06, P = 0.0069). These genomic regions may contain genes that influence interindividual variation in LDL particle size and potentially coronary heart disease susceptibility in African Americans. | lld:pubmed |
| pubmed-article:16625024 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16625024 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16625024 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16625024 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16625024 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16625024 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16625024 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16625024 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:16625024 | pubmed:issn | 0022-2275 | lld:pubmed |
| pubmed-article:16625024 | pubmed:author | pubmed-author:BoerwinkleEri... | lld:pubmed |
| pubmed-article:16625024 | pubmed:author | pubmed-author:de... | lld:pubmed |
| pubmed-article:16625024 | pubmed:author | pubmed-author:TurnerStephen... | lld:pubmed |
| pubmed-article:16625024 | pubmed:author | pubmed-author:DingKeyueK | lld:pubmed |
| pubmed-article:16625024 | pubmed:author | pubmed-author:KulloIftikhar... | lld:pubmed |
| pubmed-article:16625024 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16625024 | pubmed:volume | 47 | lld:pubmed |
| pubmed-article:16625024 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16625024 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16625024 | pubmed:pagination | 1457-62 | lld:pubmed |
| pubmed-article:16625024 | pubmed:dateRevised | 2011-8-9 | lld:pubmed |
| pubmed-article:16625024 | pubmed:meshHeading | pubmed-meshheading:16625024... | lld:pubmed |
| pubmed-article:16625024 | pubmed:meshHeading | pubmed-meshheading:16625024... | lld:pubmed |
| pubmed-article:16625024 | pubmed:meshHeading | pubmed-meshheading:16625024... | lld:pubmed |
| pubmed-article:16625024 | pubmed:meshHeading | pubmed-meshheading:16625024... | lld:pubmed |
| pubmed-article:16625024 | pubmed:meshHeading | pubmed-meshheading:16625024... | lld:pubmed |
| pubmed-article:16625024 | pubmed:meshHeading | pubmed-meshheading:16625024... | lld:pubmed |
| pubmed-article:16625024 | pubmed:meshHeading | pubmed-meshheading:16625024... | lld:pubmed |
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| pubmed-article:16625024 | pubmed:meshHeading | pubmed-meshheading:16625024... | lld:pubmed |
| pubmed-article:16625024 | pubmed:meshHeading | pubmed-meshheading:16625024... | lld:pubmed |
| pubmed-article:16625024 | pubmed:meshHeading | pubmed-meshheading:16625024... | lld:pubmed |
| pubmed-article:16625024 | pubmed:meshHeading | pubmed-meshheading:16625024... | lld:pubmed |
| pubmed-article:16625024 | pubmed:meshHeading | pubmed-meshheading:16625024... | lld:pubmed |
| pubmed-article:16625024 | pubmed:meshHeading | pubmed-meshheading:16625024... | lld:pubmed |
| pubmed-article:16625024 | pubmed:meshHeading | pubmed-meshheading:16625024... | lld:pubmed |
| pubmed-article:16625024 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16625024 | pubmed:articleTitle | Quantitative trait loci influencing low density lipoprotein particle size in African Americans. | lld:pubmed |
| pubmed-article:16625024 | pubmed:affiliation | Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA. kullo.iftikhar@mayo.edu | lld:pubmed |
| pubmed-article:16625024 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16625024 | pubmed:publicationType | Multicenter Study | lld:pubmed |
| pubmed-article:16625024 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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