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pubmed-article:16622477pubmed:abstractTextAt present, we only have indirect knowledge of the protective role of antigen-specific T cells in human viral infections, and it has been difficult to show a direct correlation between quantitative and qualitative measures of T-cell immunity and virus-associated diseases. However, as described in this Opinion article, recent advances in the characterization of T-cell functions and in the development of standardized T-cell assays have led to the identification of distinct functional signatures of T-cell responses that correlate with levels of viral replication and disease activity.lld:pubmed
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pubmed-article:16622477pubmed:articleTitleFunctional signatures in antiviral T-cell immunity for monitoring virus-associated diseases.lld:pubmed
pubmed-article:16622477pubmed:affiliationLaboratory of AIDS Immunopathogenesis, Division of Immunology and Allergy, Department of Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, 1011 Lausanne, Switzerland. giuseppe.pantaleo@chuv.chlld:pubmed
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