| pubmed-article:16622020 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16622020 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:16622020 | lifeskim:mentions | umls-concept:C0597298 | lld:lifeskim |
| pubmed-article:16622020 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16622020 | lifeskim:mentions | umls-concept:C1539102 | lld:lifeskim |
| pubmed-article:16622020 | lifeskim:mentions | umls-concept:C0916194 | lld:lifeskim |
| pubmed-article:16622020 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:16622020 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:16622020 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:16622020 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:16622020 | pubmed:dateCreated | 2006-4-19 | lld:pubmed |
| pubmed-article:16622020 | pubmed:abstractText | Dectin-1 is a specific receptor for beta-glucans and a major receptor for fungal particles on macrophages (Mphi). It is a type II membrane receptor that has a C-terminal, NK-like, C-type lectin-like domain separated from the cell membrane by a short stalk region and a cytoplasmic immunoreceptor tyrosine-based activation-like motif. We observed functional differences in dectin-1-dependent recognition of fungal particles by Mphi from different mouse strains. RT-PCR analysis revealed that mice have at least two splice forms of dectin-1, generated by differential usage of exon 3, encoding the full-length dectin-1A and a stalkless Mphi dectin-1B. Mphi from BALB/c mice and genetically related mice expressed both isoforms in similar amounts, whereas Mphi from C57BL/6 and related mice mainly expressed the smaller isoform. NIH-3T3 fibroblast and RAW264.7 macrophage cell lines stably expressing either isoform were able to bind and phagocytose zymosan at 37 degrees C. However, binding by the smaller dectin-1B isoform was significantly affected at lower temperatures. These properties were shared by the equivalent human isoforms. The relative ability of each of the isoforms to induce TNF-alpha production in RAW264.7 Mphi was also found to be different. These results are the first evidence that dectin-1 isoforms are functionally distinct and indicate that differential isoform usage may represent a mechanism of regulating cellular responses to beta-glucans. | lld:pubmed |
| pubmed-article:16622020 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16622020 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16622020 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16622020 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16622020 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16622020 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:16622020 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16622020 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16622020 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16622020 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16622020 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16622020 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16622020 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16622020 | pubmed:month | May | lld:pubmed |
| pubmed-article:16622020 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:16622020 | pubmed:author | pubmed-author:GordonSiamonS | lld:pubmed |
| pubmed-article:16622020 | pubmed:author | pubmed-author:WilliamsDavid... | lld:pubmed |
| pubmed-article:16622020 | pubmed:author | pubmed-author:TaylorPhilip... | lld:pubmed |
| pubmed-article:16622020 | pubmed:author | pubmed-author:BrownGordon... | lld:pubmed |
| pubmed-article:16622020 | pubmed:author | pubmed-author:WillmentJanet... | lld:pubmed |
| pubmed-article:16622020 | pubmed:author | pubmed-author:RosasMarcelaM | lld:pubmed |
| pubmed-article:16622020 | pubmed:author | pubmed-author:HeinsbroekSig... | lld:pubmed |
| pubmed-article:16622020 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16622020 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16622020 | pubmed:volume | 176 | lld:pubmed |
| pubmed-article:16622020 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16622020 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16622020 | pubmed:pagination | 5513-8 | lld:pubmed |
| pubmed-article:16622020 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:16622020 | pubmed:meshHeading | pubmed-meshheading:16622020... | lld:pubmed |
| pubmed-article:16622020 | pubmed:meshHeading | pubmed-meshheading:16622020... | lld:pubmed |
| pubmed-article:16622020 | pubmed:meshHeading | pubmed-meshheading:16622020... | lld:pubmed |
| pubmed-article:16622020 | pubmed:meshHeading | pubmed-meshheading:16622020... | lld:pubmed |
| pubmed-article:16622020 | pubmed:meshHeading | pubmed-meshheading:16622020... | lld:pubmed |
| pubmed-article:16622020 | pubmed:meshHeading | pubmed-meshheading:16622020... | lld:pubmed |
| pubmed-article:16622020 | pubmed:meshHeading | pubmed-meshheading:16622020... | lld:pubmed |
| pubmed-article:16622020 | pubmed:meshHeading | pubmed-meshheading:16622020... | lld:pubmed |
| pubmed-article:16622020 | pubmed:meshHeading | pubmed-meshheading:16622020... | lld:pubmed |
| pubmed-article:16622020 | pubmed:meshHeading | pubmed-meshheading:16622020... | lld:pubmed |
| pubmed-article:16622020 | pubmed:meshHeading | pubmed-meshheading:16622020... | lld:pubmed |
| pubmed-article:16622020 | pubmed:meshHeading | pubmed-meshheading:16622020... | lld:pubmed |
| pubmed-article:16622020 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16622020 | pubmed:articleTitle | Expression of functionally different dectin-1 isoforms by murine macrophages. | lld:pubmed |
| pubmed-article:16622020 | pubmed:affiliation | Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom. | lld:pubmed |
| pubmed-article:16622020 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16622020 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16622020 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:56644 | entrezgene:pubmed | pubmed-article:16622020 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16622020 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16622020 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16622020 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16622020 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16622020 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16622020 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16622020 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16622020 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16622020 | lld:pubmed |
