| pubmed-article:16619184 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16619184 | lifeskim:mentions | umls-concept:C0220847 | lld:lifeskim |
| pubmed-article:16619184 | lifeskim:mentions | umls-concept:C1704256 | lld:lifeskim |
| pubmed-article:16619184 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:16619184 | lifeskim:mentions | umls-concept:C1515406 | lld:lifeskim |
| pubmed-article:16619184 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:16619184 | lifeskim:mentions | umls-concept:C0449297 | lld:lifeskim |
| pubmed-article:16619184 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:16619184 | lifeskim:mentions | umls-concept:C0205296 | lld:lifeskim |
| pubmed-article:16619184 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:16619184 | pubmed:dateCreated | 2006-4-18 | lld:pubmed |
| pubmed-article:16619184 | pubmed:abstractText | Transforming growth factor (TGF)-beta 1 suppresses the proliferation and cytotoxicity of natural killer (NK) cells, which play critical roles in resolving hepatitis C virus (HCV) infection, especially during the acute phase. We examined 230 anti-HCV antibody-positive subjects for HCV RNA and the -509T/C genotype in the TGF-beta 1 gene promoter. The -509CC genotype and the -509C allele were significantly associated with higher HCV clearance rates (P=.01) and with lower transcriptional activity. The genetic effect remained significant even after adjustment for a history of transfusion. Low TGF- beta 1 producers might have less suppression of NK cells and be more likely to resolve HCV infection. | lld:pubmed |
| pubmed-article:16619184 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16619184 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16619184 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:16619184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16619184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16619184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16619184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16619184 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16619184 | pubmed:month | May | lld:pubmed |
| pubmed-article:16619184 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:16619184 | pubmed:author | pubmed-author:SaitoTakafumi... | lld:pubmed |
| pubmed-article:16619184 | pubmed:author | pubmed-author:KawataSumioS | lld:pubmed |
| pubmed-article:16619184 | pubmed:author | pubmed-author:BabaMasanoriM | lld:pubmed |
| pubmed-article:16619184 | pubmed:author | pubmed-author:YoshimuraMika... | lld:pubmed |
| pubmed-article:16619184 | pubmed:author | pubmed-author:KimuraTomomiT | lld:pubmed |
| pubmed-article:16619184 | pubmed:author | pubmed-author:MuramatsuMasa... | lld:pubmed |
| pubmed-article:16619184 | pubmed:author | pubmed-author:JiGuijinG | lld:pubmed |
| pubmed-article:16619184 | pubmed:author | pubmed-author:YixuanSongS | lld:pubmed |
| pubmed-article:16619184 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16619184 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16619184 | pubmed:volume | 193 | lld:pubmed |
| pubmed-article:16619184 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16619184 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16619184 | pubmed:pagination | 1371-4 | lld:pubmed |
| pubmed-article:16619184 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:16619184 | pubmed:meshHeading | pubmed-meshheading:16619184... | lld:pubmed |
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| pubmed-article:16619184 | pubmed:meshHeading | pubmed-meshheading:16619184... | lld:pubmed |
| pubmed-article:16619184 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16619184 | pubmed:articleTitle | Association of transforming growth factor-beta 1 functional polymorphisms with natural clearance of hepatitis C virus. | lld:pubmed |
| pubmed-article:16619184 | pubmed:affiliation | Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan. | lld:pubmed |
| pubmed-article:16619184 | pubmed:publicationType | Journal Article | lld:pubmed |
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