| pubmed-article:1661721 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1661721 | lifeskim:mentions | umls-concept:C0031312 | lld:lifeskim |
| pubmed-article:1661721 | lifeskim:mentions | umls-concept:C0751982 | lld:lifeskim |
| pubmed-article:1661721 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:1661721 | lifeskim:mentions | umls-concept:C0162336 | lld:lifeskim |
| pubmed-article:1661721 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
| pubmed-article:1661721 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1661721 | pubmed:dateCreated | 1992-2-5 | lld:pubmed |
| pubmed-article:1661721 | pubmed:abstractText | The aim of this study was to determine whether phalloidin (1 microM) or antamanide (1 microM), cyclic peptides that stabilize dense peripheral band and stress fiber F-actin in endothelium, would attenuate the increase in microvascular permeability induced by 4 h of ischemia and 30 min of reperfusion (I/R) in the isolated canine gracilis muscle. Changes in microvascular permeability (1 - sigma) were assessed by determining the solvent drag reflection coefficient for total plasma proteins (sigma) in muscles subjected to 4.5 h of continuous perfusion (nonischemic controls), I/R alone, I/R + phalloidin, or I/R + antamanide. Muscle neutrophil content was assessed by determination of myeloperoxidase (MPO) activity in tissue samples obtained at the end of the experiments. Fluorescent detection of nitrobenzoxadiazole-phallicidin in endothelial cell monolayers confirmed that phalloidin enters these cells. I/R was associated with marked increases in microvascular permeability and muscle neutrophil content (1 - sigma = 0.45 +/- 0.07; MPO = 8.9 +/- 0.5 units/g) relative to control (4.5 h continuous perfusion) preparations (1 - sigma = 0.12 +/- 0.03; MPO = 0.5 +/- 0.8 unit/g). These I/R-induced changes were largely prevented by administration of phalloidin (1 - sigma = 0.19 +/- 0.02; MPO = 0.8 +/- 0.4 U/g) or antamanide (1 - sigma = 0.07 +/- 0.11; MPO = 0.9 +/- 0.3 unit/g) at reperfusion. Similar results were obtained when phalloidin was administered before ischemia (1 - sigma = 0.24 +/- 0.04; MPO = 1.2 +/- 1.0 units/g). Although antamanide decreased superoxide production (by approximately 60%) and adherence to plastic (by approximately 75%) by activated neutrophils in vitro, phalloidin failed to alter these aspects of granulocyte function.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:1661721 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1661721 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1661721 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1661721 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1661721 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1661721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1661721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1661721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1661721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1661721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1661721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1661721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1661721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1661721 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1661721 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1661721 | pubmed:issn | 8750-7587 | lld:pubmed |
| pubmed-article:1661721 | pubmed:author | pubmed-author:SheproDD | lld:pubmed |
| pubmed-article:1661721 | pubmed:author | pubmed-author:KvietysP RPR | lld:pubmed |
| pubmed-article:1661721 | pubmed:author | pubmed-author:FuselerJJ | lld:pubmed |
| pubmed-article:1661721 | pubmed:author | pubmed-author:KorthuisR JRJ | lld:pubmed |
| pubmed-article:1661721 | pubmed:author | pubmed-author:CardenD LDL | lld:pubmed |
| pubmed-article:1661721 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1661721 | pubmed:volume | 71 | lld:pubmed |
| pubmed-article:1661721 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1661721 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1661721 | pubmed:pagination | 1261-9 | lld:pubmed |
| pubmed-article:1661721 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:1661721 | pubmed:meshHeading | pubmed-meshheading:1661721-... | lld:pubmed |
| pubmed-article:1661721 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1661721 | pubmed:articleTitle | Phalloidin attenuates postischemic neutrophil infiltration and increased microvascular permeability. | lld:pubmed |
| pubmed-article:1661721 | pubmed:affiliation | Department of Physiology, Louisiana State University Medical Center, School of Medicine, Shreveport 71130. | lld:pubmed |
| pubmed-article:1661721 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1661721 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1661721 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
