| pubmed-article:16617164 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16617164 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:16617164 | lifeskim:mentions | umls-concept:C0001471 | lld:lifeskim |
| pubmed-article:16617164 | lifeskim:mentions | umls-concept:C0079419 | lld:lifeskim |
| pubmed-article:16617164 | lifeskim:mentions | umls-concept:C1706968 | lld:lifeskim |
| pubmed-article:16617164 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:16617164 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:16617164 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16617164 | pubmed:dateCreated | 2006-7-19 | lld:pubmed |
| pubmed-article:16617164 | pubmed:abstractText | Blockage of the p53 tumor suppressor has been found to impair nerve growth factor (NGF)-induced neurite outgrowth in PC-12 cells. We report herein that such impairment could be rescued by stimulation of the A(2A) adenosine receptor (A(2A)-R), a G protein-coupled receptor implicated in neuronal plasticity. The A(2A)-R-mediated rescue occurred in the presence of protein kinase C (PKC) inhibitors or protein kinase A (PKA) inhibitors and in a PKA-deficient PC-12 variant. Thus, neither PKA nor PKC was involved. In contrast, expression of a truncated A(2A)-R mutant harboring the seventh transmembrane domain and its C terminus reduced the rescue effect of A(2A)-R. Using the cytoplasmic tail of the A(2A)-R as bait, a novel-A(2A)-R-interacting protein [translin-associated protein X (TRAX)] was identified in a yeast two-hybrid screen. The authenticity of this interaction was verified by pull-down experiments, coimmunoprecipitation, and colocalization of these two molecules in the brain. It is noteworthy that reduction of TRAX using an antisense construct suppressed the rescue effect of A(2A)-R, whereas overexpression of TRAX alone caused the same rescue effect as did A(2A)-R activation. Results of [(3)H]thymidine and bromodeoxyuridine incorporation suggested that A(2A)-R stimulation inhibited cell proliferation in a TRAX-dependent manner. Because the antimitotic activity is crucial for NGF function, the A(2A)-R might exert its rescue effect through a TRAX-mediated antiproliferative signal. This antimitotic activity of the A(2A)-R also enables a mitogenic factor (epidermal growth factor) to induce neurite outgrowth. We demonstrate that the A(2A)-R modulates the differentiation ability of trophic factors through a novel interacting protein, TRAX. | lld:pubmed |
| pubmed-article:16617164 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16617164 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16617164 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16617164 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16617164 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16617164 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16617164 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16617164 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16617164 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16617164 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16617164 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16617164 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16617164 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16617164 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16617164 | pubmed:issn | 0026-895X | lld:pubmed |
| pubmed-article:16617164 | pubmed:author | pubmed-author:LaiHsing-LinH... | lld:pubmed |
| pubmed-article:16617164 | pubmed:author | pubmed-author:SunChung-NanC... | lld:pubmed |
| pubmed-article:16617164 | pubmed:author | pubmed-author:ChernYijuangY | lld:pubmed |
| pubmed-article:16617164 | pubmed:author | pubmed-author:ChengHsiao-Ch... | lld:pubmed |
| pubmed-article:16617164 | pubmed:author | pubmed-author:LinYa-WenYW | lld:pubmed |
| pubmed-article:16617164 | pubmed:author | pubmed-author:ChouJui-LingJ... | lld:pubmed |
| pubmed-article:16617164 | pubmed:author | pubmed-author:LeeShen-YangS... | lld:pubmed |
| pubmed-article:16617164 | pubmed:author | pubmed-author:ChenHui-MeiHM | lld:pubmed |
| pubmed-article:16617164 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16617164 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:16617164 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16617164 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16617164 | pubmed:pagination | 454-66 | lld:pubmed |
| pubmed-article:16617164 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:16617164 | pubmed:meshHeading | pubmed-meshheading:16617164... | lld:pubmed |
| pubmed-article:16617164 | pubmed:meshHeading | pubmed-meshheading:16617164... | lld:pubmed |
| pubmed-article:16617164 | pubmed:meshHeading | pubmed-meshheading:16617164... | lld:pubmed |
| pubmed-article:16617164 | pubmed:meshHeading | pubmed-meshheading:16617164... | lld:pubmed |
| pubmed-article:16617164 | pubmed:meshHeading | pubmed-meshheading:16617164... | lld:pubmed |
| pubmed-article:16617164 | pubmed:meshHeading | pubmed-meshheading:16617164... | lld:pubmed |
| pubmed-article:16617164 | pubmed:meshHeading | pubmed-meshheading:16617164... | lld:pubmed |
| pubmed-article:16617164 | pubmed:meshHeading | pubmed-meshheading:16617164... | lld:pubmed |
| pubmed-article:16617164 | pubmed:meshHeading | pubmed-meshheading:16617164... | lld:pubmed |
| pubmed-article:16617164 | pubmed:meshHeading | pubmed-meshheading:16617164... | lld:pubmed |
| pubmed-article:16617164 | pubmed:meshHeading | pubmed-meshheading:16617164... | lld:pubmed |
| pubmed-article:16617164 | pubmed:meshHeading | pubmed-meshheading:16617164... | lld:pubmed |
| pubmed-article:16617164 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16617164 | pubmed:articleTitle | Rescue of p53 blockage by the A(2A) adenosine receptor via a novel interacting protein, translin-associated protein X. | lld:pubmed |
| pubmed-article:16617164 | pubmed:affiliation | Institute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan. | lld:pubmed |
| pubmed-article:16617164 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16617164 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:11540 | entrezgene:pubmed | pubmed-article:16617164 | lld:entrezgene |
| entrez-gene:53424 | entrezgene:pubmed | pubmed-article:16617164 | lld:entrezgene |
| entrez-gene:25369 | entrezgene:pubmed | pubmed-article:16617164 | lld:entrezgene |
| entrez-gene:64028 | entrezgene:pubmed | pubmed-article:16617164 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16617164 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16617164 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16617164 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16617164 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16617164 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16617164 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16617164 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16617164 | lld:pubmed |
