Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:16614756rdf:typepubmed:Citationlld:pubmed
pubmed-article:16614756lifeskim:mentionsumls-concept:C0007227lld:lifeskim
pubmed-article:16614756lifeskim:mentionsumls-concept:C0033551lld:lifeskim
pubmed-article:16614756lifeskim:mentionsumls-concept:C1419067lld:lifeskim
pubmed-article:16614756pubmed:issue5lld:pubmed
pubmed-article:16614756pubmed:dateCreated2006-5-3lld:pubmed
pubmed-article:16614756pubmed:abstractTextWe investigated the mechanisms by which inhibitors of prostaglandin G/H synthase-2 (PGHS-2; known colloquially as COX-2) increase the incidence of myocardial infarction and stroke. These inhibitors are believed to exert both their beneficial and their adverse effects by suppression of PGHS-2-derived prostacyclin (PGI(2)) and PGE(2). Therefore, the challenge remains to identify a mechanism whereby PGI(2) and PGE(2) expression can be suppressed while avoiding adverse cardiovascular events. Here, selective inhibition, knockout, or mutation of PGHS-2, or deletion of the receptor for PGHS-2-derived PGI(2), was shown to accelerate thrombogenesis and elevate blood pressure in mice. These responses were attenuated by COX-1 knock down, which mimics the beneficial effects of low-dose aspirin. PGE(2) biosynthesis is catalyzed by the coordinate actions of COX enzymes and microsomal PGE synthase-1 (mPGES-1). We show that deletion of mPGES-1 depressed PGE(2) expression, augmented PGI(2) expression, and had no effect on thromboxane biosynthesis in vivo. Most importantly, mPGES-1 deletion affected neither thrombogenesis nor blood pressure. These results suggest that inhibitors of mPGES-1 may retain their antiinflammatory efficacy by depressing PGE(2), while avoiding the adverse cardiovascular consequences associated with PGHS-2-mediated PGI(2) suppression.lld:pubmed
pubmed-article:16614756pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:languageenglld:pubmed
pubmed-article:16614756pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:citationSubsetAIMlld:pubmed
pubmed-article:16614756pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16614756pubmed:statusMEDLINElld:pubmed
pubmed-article:16614756pubmed:monthMaylld:pubmed
pubmed-article:16614756pubmed:issn0021-9738lld:pubmed
pubmed-article:16614756pubmed:authorpubmed-author:FunkColin DCDlld:pubmed
pubmed-article:16614756pubmed:authorpubmed-author:YuYingYlld:pubmed
pubmed-article:16614756pubmed:authorpubmed-author:WangMiaoMlld:pubmed
pubmed-article:16614756pubmed:authorpubmed-author:ChengYanYlld:pubmed
pubmed-article:16614756pubmed:authorpubmed-author:FitzgeraldGar...lld:pubmed
pubmed-article:16614756pubmed:authorpubmed-author:LawsonJohnJlld:pubmed
pubmed-article:16614756pubmed:issnTypePrintlld:pubmed
pubmed-article:16614756pubmed:volume116lld:pubmed
pubmed-article:16614756pubmed:ownerNLMlld:pubmed
pubmed-article:16614756pubmed:authorsCompleteYlld:pubmed
pubmed-article:16614756pubmed:pagination1391-9lld:pubmed
pubmed-article:16614756pubmed:dateRevised2009-11-18lld:pubmed
pubmed-article:16614756pubmed:meshHeadingpubmed-meshheading:16614756...lld:pubmed
pubmed-article:16614756pubmed:meshHeadingpubmed-meshheading:16614756...lld:pubmed
pubmed-article:16614756pubmed:meshHeadingpubmed-meshheading:16614756...lld:pubmed
pubmed-article:16614756pubmed:meshHeadingpubmed-meshheading:16614756...lld:pubmed
pubmed-article:16614756pubmed:meshHeadingpubmed-meshheading:16614756...lld:pubmed
pubmed-article:16614756pubmed:meshHeadingpubmed-meshheading:16614756...lld:pubmed
pubmed-article:16614756pubmed:meshHeadingpubmed-meshheading:16614756...lld:pubmed
pubmed-article:16614756pubmed:meshHeadingpubmed-meshheading:16614756...lld:pubmed
pubmed-article:16614756pubmed:meshHeadingpubmed-meshheading:16614756...lld:pubmed
pubmed-article:16614756pubmed:meshHeadingpubmed-meshheading:16614756...lld:pubmed
More...