| pubmed-article:16614214 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16614214 | lifeskim:mentions | umls-concept:C0443286 | lld:lifeskim |
| pubmed-article:16614214 | lifeskim:mentions | umls-concept:C0678257 | lld:lifeskim |
| pubmed-article:16614214 | lifeskim:mentions | umls-concept:C0033727 | lld:lifeskim |
| pubmed-article:16614214 | lifeskim:mentions | umls-concept:C0765250 | lld:lifeskim |
| pubmed-article:16614214 | pubmed:issue | 5771 | lld:pubmed |
| pubmed-article:16614214 | pubmed:dateCreated | 2006-4-14 | lld:pubmed |
| pubmed-article:16614214 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16614214 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16614214 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16614214 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16614214 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16614214 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16614214 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16614214 | pubmed:abstractText | We present an atomic-level description of the reaction chemistry of an enzyme-catalyzed reaction dominated by proton tunneling. By solving structures of reaction intermediates at near-atomic resolution, we have identified the reaction pathway for tryptamine oxidation by aromatic amine dehydrogenase. Combining experiment and computer simulation, we show proton transfer occurs predominantly to oxygen O2 of Asp(128)beta in a reaction dominated by tunneling over approximately 0.6 angstroms. The role of long-range coupled motions in promoting tunneling is controversial. We show that, in this enzyme system, tunneling is promoted by a short-range motion modulating proton-acceptor distance and no long-range coupled motion is required. | lld:pubmed |
| pubmed-article:16614214 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16614214 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16614214 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16614214 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16614214 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16614214 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16614214 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16614214 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16614214 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16614214 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16614214 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16614214 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16614214 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16614214 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16614214 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:16614214 | pubmed:issn | 1095-9203 | lld:pubmed |
| pubmed-article:16614214 | pubmed:author | pubmed-author:SutcliffeMich... | lld:pubmed |
| pubmed-article:16614214 | pubmed:author | pubmed-author:ScruttonNigel... | lld:pubmed |
| pubmed-article:16614214 | pubmed:author | pubmed-author:RoujeinikovaA... | lld:pubmed |
| pubmed-article:16614214 | pubmed:author | pubmed-author:LeysDavidD | lld:pubmed |
| pubmed-article:16614214 | pubmed:author | pubmed-author:BasranJaswirJ | lld:pubmed |
| pubmed-article:16614214 | pubmed:author | pubmed-author:MulhollandAdr... | lld:pubmed |
| pubmed-article:16614214 | pubmed:author | pubmed-author:MasgrauLauraL | lld:pubmed |
| pubmed-article:16614214 | pubmed:author | pubmed-author:HothiParvinde... | lld:pubmed |
| pubmed-article:16614214 | pubmed:author | pubmed-author:JohannissenLi... | lld:pubmed |
| pubmed-article:16614214 | pubmed:author | pubmed-author:RanaghanKara... | lld:pubmed |
| pubmed-article:16614214 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:16614214 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:16614214 | pubmed:volume | 312 | lld:pubmed |
| pubmed-article:16614214 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16614214 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16614214 | pubmed:pagination | 237-41 | lld:pubmed |
| pubmed-article:16614214 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:16614214 | pubmed:meshHeading | pubmed-meshheading:16614214... | lld:pubmed |
| pubmed-article:16614214 | pubmed:meshHeading | pubmed-meshheading:16614214... | lld:pubmed |
| pubmed-article:16614214 | pubmed:meshHeading | pubmed-meshheading:16614214... | lld:pubmed |
| pubmed-article:16614214 | pubmed:meshHeading | pubmed-meshheading:16614214... | lld:pubmed |
| pubmed-article:16614214 | pubmed:meshHeading | pubmed-meshheading:16614214... | lld:pubmed |
| pubmed-article:16614214 | pubmed:meshHeading | pubmed-meshheading:16614214... | lld:pubmed |
| pubmed-article:16614214 | pubmed:meshHeading | pubmed-meshheading:16614214... | lld:pubmed |
| pubmed-article:16614214 | pubmed:meshHeading | pubmed-meshheading:16614214... | lld:pubmed |
| pubmed-article:16614214 | pubmed:meshHeading | pubmed-meshheading:16614214... | lld:pubmed |
| pubmed-article:16614214 | pubmed:meshHeading | pubmed-meshheading:16614214... | lld:pubmed |
| pubmed-article:16614214 | pubmed:meshHeading | pubmed-meshheading:16614214... | lld:pubmed |
| pubmed-article:16614214 | pubmed:meshHeading | pubmed-meshheading:16614214... | lld:pubmed |
| pubmed-article:16614214 | pubmed:meshHeading | pubmed-meshheading:16614214... | lld:pubmed |
| pubmed-article:16614214 | pubmed:meshHeading | pubmed-meshheading:16614214... | lld:pubmed |
| pubmed-article:16614214 | pubmed:meshHeading | pubmed-meshheading:16614214... | lld:pubmed |
| pubmed-article:16614214 | pubmed:meshHeading | pubmed-meshheading:16614214... | lld:pubmed |
| pubmed-article:16614214 | pubmed:meshHeading | pubmed-meshheading:16614214... | lld:pubmed |
| pubmed-article:16614214 | pubmed:meshHeading | pubmed-meshheading:16614214... | lld:pubmed |
| pubmed-article:16614214 | pubmed:meshHeading | pubmed-meshheading:16614214... | lld:pubmed |
| pubmed-article:16614214 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16614214 | pubmed:articleTitle | Atomic description of an enzyme reaction dominated by proton tunneling. | lld:pubmed |
| pubmed-article:16614214 | pubmed:affiliation | Manchester Interdisciplinary Biocentre, University of Manchester, Jackson's Mill, Post Office Box 88, Manchester M60 1QD, UK. | lld:pubmed |
| pubmed-article:16614214 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16614214 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| literatureCitation:6871_166... | literatureCitation:pubmed | pubmed-article:16614214 | lld:drugbank |
| literatureCitation:6872_166... | literatureCitation:pubmed | pubmed-article:16614214 | lld:drugbank |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16614214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16614214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16614214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16614214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16614214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16614214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16614214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16614214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16614214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16614214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16614214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16614214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16614214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16614214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16614214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16614214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16614214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16614214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16614214 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16614214 | lld:pubmed |
