| pubmed-article:16611810 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:16611810 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:16611810 | lifeskim:mentions | umls-concept:C0003069 | lld:lifeskim |
| pubmed-article:16611810 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:16611810 | lifeskim:mentions | umls-concept:C0028936 | lld:lifeskim |
| pubmed-article:16611810 | lifeskim:mentions | umls-concept:C0038590 | lld:lifeskim |
| pubmed-article:16611810 | lifeskim:mentions | umls-concept:C0085200 | lld:lifeskim |
| pubmed-article:16611810 | lifeskim:mentions | umls-concept:C0285890 | lld:lifeskim |
| pubmed-article:16611810 | lifeskim:mentions | umls-concept:C0282151 | lld:lifeskim |
| pubmed-article:16611810 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:16611810 | lifeskim:mentions | umls-concept:C1521733 | lld:lifeskim |
| pubmed-article:16611810 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:16611810 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:16611810 | pubmed:dateCreated | 2006-4-13 | lld:pubmed |
| pubmed-article:16611810 | pubmed:abstractText | Dysfunction of the 140 aa protein alpha-synuclein plays a central role in Lewy body disorders, including Parkinson's disease, as well as in multiple system atrophy. Here, we show that the expression of truncated human alpha-synuclein(1-120), driven by the rat tyrosine hydroxylase promoter on a mouse alpha-synuclein null background, leads to the formation of pathological inclusions in the substantia nigra and olfactory bulb and to a reduction in striatal dopamine levels. At the behavioral level, the transgenic mice showed a progressive reduction in spontaneous locomotion and an increased response to amphetamine. These findings suggest that the C-terminal of alpha-synuclein is an important regulator of aggregation in vivo and will help to understand the mechanisms underlying the pathogenesis of Lewy body disorders and multiple system atrophy. | lld:pubmed |
| pubmed-article:16611810 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16611810 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16611810 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16611810 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16611810 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16611810 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16611810 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16611810 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:16611810 | pubmed:issn | 1529-2401 | lld:pubmed |
| pubmed-article:16611810 | pubmed:author | pubmed-author:GoedertMichel... | lld:pubmed |
| pubmed-article:16611810 | pubmed:author | pubmed-author:EmsonPiers... | lld:pubmed |
| pubmed-article:16611810 | pubmed:author | pubmed-author:WilkinsonLawr... | lld:pubmed |
| pubmed-article:16611810 | pubmed:author | pubmed-author:GhettiBernard... | lld:pubmed |
| pubmed-article:16611810 | pubmed:author | pubmed-author:TofarisGeorge... | lld:pubmed |
| pubmed-article:16611810 | pubmed:author | pubmed-author:SpillantiniMa... | lld:pubmed |
| pubmed-article:16611810 | pubmed:author | pubmed-author:HumbyTrevorT | lld:pubmed |
| pubmed-article:16611810 | pubmed:author | pubmed-author:O'ConnellMark... | lld:pubmed |
| pubmed-article:16611810 | pubmed:author | pubmed-author:LambourneSara... | lld:pubmed |
| pubmed-article:16611810 | pubmed:author | pubmed-author:Garcia... | lld:pubmed |
| pubmed-article:16611810 | pubmed:author | pubmed-author:GossageHelenH | lld:pubmed |
| pubmed-article:16611810 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:16611810 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:16611810 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:16611810 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16611810 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16611810 | pubmed:pagination | 3942-50 | lld:pubmed |
| pubmed-article:16611810 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:16611810 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16611810 | pubmed:articleTitle | Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders. | lld:pubmed |
| pubmed-article:16611810 | pubmed:affiliation | Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 2PY, United Kingdom. | lld:pubmed |
| pubmed-article:16611810 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16611810 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16611810 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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