| pubmed-article:16611416 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16611416 | lifeskim:mentions | umls-concept:C0085669 | lld:lifeskim |
| pubmed-article:16611416 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:16611416 | lifeskim:mentions | umls-concept:C0026473 | lld:lifeskim |
| pubmed-article:16611416 | lifeskim:mentions | umls-concept:C1749467 | lld:lifeskim |
| pubmed-article:16611416 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:16611416 | lifeskim:mentions | umls-concept:C1415587 | lld:lifeskim |
| pubmed-article:16611416 | lifeskim:mentions | umls-concept:C0449560 | lld:lifeskim |
| pubmed-article:16611416 | lifeskim:mentions | umls-concept:C0392760 | lld:lifeskim |
| pubmed-article:16611416 | lifeskim:mentions | umls-concept:C1518071 | lld:lifeskim |
| pubmed-article:16611416 | lifeskim:mentions | umls-concept:C1881379 | lld:lifeskim |
| pubmed-article:16611416 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16611416 | pubmed:dateCreated | 2006-4-13 | lld:pubmed |
| pubmed-article:16611416 | pubmed:abstractText | Human leukocyte antigen G (HLA-G) molecules exhibit immunomodulatory properties corresponding to nonclassic class I genes of the major histocompatibility complex. They are either membrane-bound or solubly expressed during certain tumoral malignancies. Soluble human leukocyte antigen G (sHLA-G) molecules seem more frequently expressed than membrane-bound isoforms during hematologic malignancies, such as lymphoproliferative disorders. Assay of these molecules by enzyme-linked immunosorbent assay in patients suffering from another hematologic disorder (acute leukemia) highlights increased sHLA-G secretion. This increased secretion seems more marked in acute leukemia subtypes affecting monocytic and lymphoid lineages such as FABM4 and FABM5, as well as both B and T acute lymphoblastic leukemia (ALL). Moreover, this study uses in vitro cytokine stimulations and reveals the respective potential roles of granulocyte-macrophage colony-stimulating factor and interferon-gamma in increasing this secretion in FABM4 and ALL. Correlations between sHLA-G plasma level and clinical biologic features suggest a link between elevated sHLA-G level and 1) the absence of anterior myelodysplasia and 2) high-level leukocytosis. All these findings suggest that sHLA-G molecules could be a factor in tumoral escape from immune survey during acute leukemia. | lld:pubmed |
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| pubmed-article:16611416 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16611416 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16611416 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16611416 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16611416 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:16611416 | pubmed:issn | 1476-5586 | lld:pubmed |
| pubmed-article:16611416 | pubmed:author | pubmed-author:AmiotLaurence... | lld:pubmed |
| pubmed-article:16611416 | pubmed:author | pubmed-author:FauchetRenéeR | lld:pubmed |
| pubmed-article:16611416 | pubmed:author | pubmed-author:BrangerBernar... | lld:pubmed |
| pubmed-article:16611416 | pubmed:author | pubmed-author:BernardMarcM | lld:pubmed |
| pubmed-article:16611416 | pubmed:author | pubmed-author:SebtiYasmineY | lld:pubmed |
| pubmed-article:16611416 | pubmed:author | pubmed-author:GrosFrédéricF | lld:pubmed |
| pubmed-article:16611416 | pubmed:author | pubmed-author:de... | lld:pubmed |
| pubmed-article:16611416 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:16611416 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:16611416 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16611416 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16611416 | pubmed:pagination | 223-30 | lld:pubmed |
| pubmed-article:16611416 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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