| pubmed-article:16610809 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16610809 | lifeskim:mentions | umls-concept:C0018282 | lld:lifeskim |
| pubmed-article:16610809 | lifeskim:mentions | umls-concept:C0032150 | lld:lifeskim |
| pubmed-article:16610809 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:16610809 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:16610809 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:16610809 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:16610809 | lifeskim:mentions | umls-concept:C0060694 | lld:lifeskim |
| pubmed-article:16610809 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:16610809 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:16610809 | pubmed:dateCreated | 2006-4-13 | lld:pubmed |
| pubmed-article:16610809 | pubmed:abstractText | A series of fosmidomycin analogues featuring restricted conformational mobility has been synthesized and evaluated as inhibitors of 1-deoxy-D-xylulose 5-phosphate (DOXP) reductoisomerase and as growth inhibitors of P. falciparum. The enantiomerically pure trans-cyclopropyl N-acetyl analogue 3b showed comparable inhibitory activity as fosmidomycin toward E. coli DOXP reductoisomerase and proved equally active when tested in vitro for P. falciparum growth inhibition. Conversely, the alpha-phenyl cis-cyclopropyl analogue 4 showed virtually no inhibition of the enzyme. | lld:pubmed |
| pubmed-article:16610809 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16610809 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16610809 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16610809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16610809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16610809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16610809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16610809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16610809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16610809 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16610809 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:16610809 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:16610809 | pubmed:author | pubmed-author:WiesnerJochen... | lld:pubmed |
| pubmed-article:16610809 | pubmed:author | pubmed-author:JomaaHassanH | lld:pubmed |
| pubmed-article:16610809 | pubmed:author | pubmed-author:Van... | lld:pubmed |
| pubmed-article:16610809 | pubmed:author | pubmed-author:Van der... | lld:pubmed |
| pubmed-article:16610809 | pubmed:author | pubmed-author:GoemanJan LJL | lld:pubmed |
| pubmed-article:16610809 | pubmed:author | pubmed-author:DevreuxVincen... | lld:pubmed |
| pubmed-article:16610809 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16610809 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:16610809 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:16610809 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16610809 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16610809 | pubmed:pagination | 2656-60 | lld:pubmed |
| pubmed-article:16610809 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:16610809 | pubmed:meshHeading | pubmed-meshheading:16610809... | lld:pubmed |
| pubmed-article:16610809 | pubmed:meshHeading | pubmed-meshheading:16610809... | lld:pubmed |
| pubmed-article:16610809 | pubmed:meshHeading | pubmed-meshheading:16610809... | lld:pubmed |
| pubmed-article:16610809 | pubmed:meshHeading | pubmed-meshheading:16610809... | lld:pubmed |
| pubmed-article:16610809 | pubmed:meshHeading | pubmed-meshheading:16610809... | lld:pubmed |
| pubmed-article:16610809 | pubmed:meshHeading | pubmed-meshheading:16610809... | lld:pubmed |
| pubmed-article:16610809 | pubmed:meshHeading | pubmed-meshheading:16610809... | lld:pubmed |
| pubmed-article:16610809 | pubmed:meshHeading | pubmed-meshheading:16610809... | lld:pubmed |
| pubmed-article:16610809 | pubmed:meshHeading | pubmed-meshheading:16610809... | lld:pubmed |
| pubmed-article:16610809 | pubmed:meshHeading | pubmed-meshheading:16610809... | lld:pubmed |
| pubmed-article:16610809 | pubmed:meshHeading | pubmed-meshheading:16610809... | lld:pubmed |
| pubmed-article:16610809 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16610809 | pubmed:articleTitle | Synthesis and biological evaluation of cyclopropyl analogues of fosmidomycin as potent Plasmodium falciparum growth inhibitors. | lld:pubmed |
| pubmed-article:16610809 | pubmed:affiliation | Laboratory for Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B-9000 Gent, Belgium. | lld:pubmed |
| pubmed-article:16610809 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16610809 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:16610809 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:16610809 | lld:chembl |
