| pubmed-article:16604083 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16604083 | lifeskim:mentions | umls-concept:C0069141 | lld:lifeskim |
| pubmed-article:16604083 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:16604083 | lifeskim:mentions | umls-concept:C0333562 | lld:lifeskim |
| pubmed-article:16604083 | lifeskim:mentions | umls-concept:C0949765 | lld:lifeskim |
| pubmed-article:16604083 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:16604083 | pubmed:dateCreated | 2006-6-1 | lld:pubmed |
| pubmed-article:16604083 | pubmed:abstractText | Nucleophosmin (NPM), an abundant, predominantly nucleolar protein that influences numerous cellular processes, was shown to specifically associate with the bodies of messenger RNAs as a result of the process of 3'-end formation. NPM deposition requires polyadenylation but not the 3' cleavage event to occur on the transcript. Furthermore, the protein does not associate with RNAs bearing a preformed poly(A) tail or with mRNAs that have undergone cleavage but not polyadenylation. A region within 10 bases upstream of the AAUAAA element is required for NPM association, but deposition of the protein seems to be sequence independent. NPM association with poly(A)(+) mRNAs was also demonstrated in vivo. NPM, therefore, represents a mark left on transcripts as a result of 3'-end processing and may have a role in one or more of a variety of post-transcriptional processes influenced by the polyadenylation event. | lld:pubmed |
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| pubmed-article:16604083 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16604083 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16604083 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16604083 | pubmed:month | May | lld:pubmed |
| pubmed-article:16604083 | pubmed:issn | 1545-9993 | lld:pubmed |
| pubmed-article:16604083 | pubmed:author | pubmed-author:WiluszJeffrey... | lld:pubmed |
| pubmed-article:16604083 | pubmed:author | pubmed-author:MoraesKaren... | lld:pubmed |
| pubmed-article:16604083 | pubmed:author | pubmed-author:WiluszCarol... | lld:pubmed |
| pubmed-article:16604083 | pubmed:author | pubmed-author:ViswanathanPa... | lld:pubmed |
| pubmed-article:16604083 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16604083 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:16604083 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16604083 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16604083 | pubmed:pagination | 429-35 | lld:pubmed |
| pubmed-article:16604083 | pubmed:dateRevised | 2011-5-6 | lld:pubmed |
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