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pubmed-article:16603361pubmed:abstractTextWe report a 45-year-old woman with acute autonomic sensory and motor neuropathy (AASMN) showing central nervous system (CNS) disturbance. She presented with disturbance of consciousness, complex partial seizures with automatisms, autonomic, sensory and motor neuropathy, showing severe orthostatic hypotension and neurogenic bladder. Nerve conduction studies and nerve biopsy indicated axonal degeneration involving both the myelinated and unmyelinated fibers. Muscle biopsy revealed neurogenic muscular atrophy. Electroencephalogram revealed theta wave activities and sharp wave abnormalities in the frontal lobe. Intravenous immunoglobulin therapy resulted in complete recovery of consciousness levels, but no obvious improvement of the other symptoms. Only eight patients with AASMN have been reported. This is the first report of AASMN showing CNS disturbance. Perivascular lymphocytic infiltration into the temporal lobe and brain stem was described in an autonomic neuropathy patient. An inflammatory pathogenesis of the CNS disturbance associated with this autonomic neuropathy was proposed.lld:pubmed
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pubmed-article:16603361pubmed:authorpubmed-author:SakaiKenjiKlld:pubmed
pubmed-article:16603361pubmed:authorpubmed-author:YamadaMasahit...lld:pubmed
pubmed-article:16603361pubmed:authorpubmed-author:MatsumotoYasu...lld:pubmed
pubmed-article:16603361pubmed:authorpubmed-author:NozakiIchiroIlld:pubmed
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pubmed-article:16603361pubmed:year2007lld:pubmed
pubmed-article:16603361pubmed:articleTitleAcute autonomic sensory and motor neuropathy associated with central nervous system disturbance.lld:pubmed
pubmed-article:16603361pubmed:affiliationDepartment of Neurology and Neurobiology of Aging, Kanazawa University Graduate, School of Medical Science, 13-1 Takaramachi, Kanazawa 920-8054, Japan. ksakai@bri.niigata-u.ac.jplld:pubmed
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