| pubmed-article:16600853 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16600853 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:16600853 | lifeskim:mentions | umls-concept:C0031760 | lld:lifeskim |
| pubmed-article:16600853 | lifeskim:mentions | umls-concept:C0035499 | lld:lifeskim |
| pubmed-article:16600853 | lifeskim:mentions | umls-concept:C0011164 | lld:lifeskim |
| pubmed-article:16600853 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:16600853 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:16600853 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:16600853 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:16600853 | lifeskim:mentions | umls-concept:C0234621 | lld:lifeskim |
| pubmed-article:16600853 | lifeskim:mentions | umls-concept:C1512167 | lld:lifeskim |
| pubmed-article:16600853 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16600853 | pubmed:dateCreated | 2006-4-7 | lld:pubmed |
| pubmed-article:16600853 | pubmed:abstractText | The death of photoreceptor cells caused by retinal degenerative diseases often results in a complete loss of retinal responses to light. We explore the feasibility of converting inner retinal neurons to photosensitive cells as a possible strategy for imparting light sensitivity to retinas lacking rods and cones. Using delivery by an adeno-associated viral vector, here, we show that long-term expression of a microbial-type rhodopsin, channelrhodopsin-2 (ChR2), can be achieved in rodent inner retinal neurons in vivo. Furthermore, we demonstrate that expression of ChR2 in surviving inner retinal neurons of a mouse with photoreceptor degeneration can restore the ability of the retina to encode light signals and transmit the light signals to the visual cortex. Thus, expression of microbial-type channelrhodopsins, such as ChR2, in surviving inner retinal neurons is a potential strategy for the restoration of vision after rod and cone degeneration. | lld:pubmed |
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| pubmed-article:16600853 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16600853 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16600853 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16600853 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16600853 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16600853 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16600853 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:16600853 | pubmed:issn | 0896-6273 | lld:pubmed |
| pubmed-article:16600853 | pubmed:author | pubmed-author:DizhoorAlexan... | lld:pubmed |
| pubmed-article:16600853 | pubmed:author | pubmed-author:PanZhuo-HuaZH | lld:pubmed |
| pubmed-article:16600853 | pubmed:author | pubmed-author:PuMingliangM | lld:pubmed |
| pubmed-article:16600853 | pubmed:author | pubmed-author:MaYu-PingYP | lld:pubmed |
| pubmed-article:16600853 | pubmed:author | pubmed-author:CuiJinjuanJ | lld:pubmed |
| pubmed-article:16600853 | pubmed:author | pubmed-author:BiAndingA | lld:pubmed |
| pubmed-article:16600853 | pubmed:author | pubmed-author:OlshevskayaEl... | lld:pubmed |
| pubmed-article:16600853 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16600853 | pubmed:day | 6 | lld:pubmed |
