| pubmed-article:16598792 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16598792 | lifeskim:mentions | umls-concept:C0023895 | lld:lifeskim |
| pubmed-article:16598792 | lifeskim:mentions | umls-concept:C0033325 | lld:lifeskim |
| pubmed-article:16598792 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:16598792 | lifeskim:mentions | umls-concept:C2239176 | lld:lifeskim |
| pubmed-article:16598792 | lifeskim:mentions | umls-concept:C0019144 | lld:lifeskim |
| pubmed-article:16598792 | lifeskim:mentions | umls-concept:C1623038 | lld:lifeskim |
| pubmed-article:16598792 | lifeskim:mentions | umls-concept:C0449820 | lld:lifeskim |
| pubmed-article:16598792 | lifeskim:mentions | umls-concept:C0205088 | lld:lifeskim |
| pubmed-article:16598792 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:16598792 | pubmed:dateCreated | 2006-5-29 | lld:pubmed |
| pubmed-article:16598792 | pubmed:abstractText | The objective of this study was to predict postoperative liver failure and morbidity after hepatectomy for hepatocellular carcinoma (HCC) with cirrhosis. The model for end-stage liver disease (MELD) score is currently accepted as a disease severity index of cirrhotic patients awaiting liver transplantation; however, its impact on prognosis after resection of HCC on cirrhosis has never been investigated. One hundred fifty-four cirrhotic patients resected in a tertiary care setting for HCC were retrospectively analyzed. For each patient, the MELD score was calculated and related to postoperative liver failure and complications (morbidity). Hospital stay and 1-year survival was also investigated. MELD accuracy in predicting postoperative liver failure and morbidity of cirrhotic patients was assessed using receiver operating characteristic (ROC) analysis. Eleven patients (7.1%) experienced postoperative liver failure leading to death or transplantation. ROC analysis identified cirrhotic patients with a MELD score equal to or above 11 at high risk for postoperative liver failure (area under the curve [AUC] = 0.92, 95% confidence interval [CI] = 0.87-0.96; sensitivity = 82%; specificity = 89%). Forty-six patients (29.9%) developed at least 1 postoperative complication: ROC analysis identified patients with a MELD score equal to or above 9 at major risk for postoperative complications (AUC = 0.85, 95% CI = 0.78-0.89; sensitivity = 87%; specificity = 63%). Cirrhotic patients with MELD score below 9 had no postoperative liver failure and low morbidity (8.1%). In conclusion, the MELD score can accurately predict postoperative liver failure and morbidity of cirrhotic patients referred for resection of HCC and should be used to select the best candidates for hepatectomy. | lld:pubmed |
| pubmed-article:16598792 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16598792 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16598792 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16598792 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16598792 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16598792 | pubmed:issn | 1527-6465 | lld:pubmed |
| pubmed-article:16598792 | pubmed:author | pubmed-author:VivarelliMarc... | lld:pubmed |
| pubmed-article:16598792 | pubmed:author | pubmed-author:RavaioliMatte... | lld:pubmed |
| pubmed-article:16598792 | pubmed:author | pubmed-author:GraziGian... | lld:pubmed |
| pubmed-article:16598792 | pubmed:author | pubmed-author:CesconMatteoM | lld:pubmed |
| pubmed-article:16598792 | pubmed:author | pubmed-author:ErcolaniGiorg... | lld:pubmed |
| pubmed-article:16598792 | pubmed:author | pubmed-author:CucchettiAles... | lld:pubmed |
| pubmed-article:16598792 | pubmed:author | pubmed-author:La... | lld:pubmed |
| pubmed-article:16598792 | pubmed:author | pubmed-author:PinnaAntonio... | lld:pubmed |
| pubmed-article:16598792 | pubmed:author | pubmed-author:ZanelloMatteo... | lld:pubmed |
| pubmed-article:16598792 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16598792 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:16598792 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16598792 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16598792 | pubmed:pagination | 966-71 | lld:pubmed |
| pubmed-article:16598792 | pubmed:meshHeading | pubmed-meshheading:16598792... | lld:pubmed |
| pubmed-article:16598792 | pubmed:meshHeading | pubmed-meshheading:16598792... | lld:pubmed |
| pubmed-article:16598792 | pubmed:meshHeading | pubmed-meshheading:16598792... | lld:pubmed |
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| pubmed-article:16598792 | pubmed:meshHeading | pubmed-meshheading:16598792... | lld:pubmed |
| pubmed-article:16598792 | pubmed:meshHeading | pubmed-meshheading:16598792... | lld:pubmed |
| pubmed-article:16598792 | pubmed:meshHeading | pubmed-meshheading:16598792... | lld:pubmed |
| pubmed-article:16598792 | pubmed:meshHeading | pubmed-meshheading:16598792... | lld:pubmed |
| pubmed-article:16598792 | pubmed:meshHeading | pubmed-meshheading:16598792... | lld:pubmed |
| pubmed-article:16598792 | pubmed:meshHeading | pubmed-meshheading:16598792... | lld:pubmed |
| pubmed-article:16598792 | pubmed:meshHeading | pubmed-meshheading:16598792... | lld:pubmed |
| pubmed-article:16598792 | pubmed:meshHeading | pubmed-meshheading:16598792... | lld:pubmed |
| pubmed-article:16598792 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16598792 | pubmed:articleTitle | Impact of model for end-stage liver disease (MELD) score on prognosis after hepatectomy for hepatocellular carcinoma on cirrhosis. | lld:pubmed |
| pubmed-article:16598792 | pubmed:affiliation | Department of Surgery and Transplantation, University of Bologna, Policlinico Sant'Orsola-Malpighi, Bologna, Italy. | lld:pubmed |
| pubmed-article:16598792 | pubmed:publicationType | Journal Article | lld:pubmed |
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