Linked Life Data

16598519

Source:http://linkedlifedata.com/resource/pubmed/id/16598519

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pubmed-article:16598519pubmed:abstractTextNicotinic acetylcholine receptors mediate the parasympathetic autonomic control of cardiac function. Aim of this study was the assessment of cardiac nicotinic acetylcholine receptor distribution with a novel (alpha4beta2) nicotinic acetylcholine receptor PET ligand (2-deoxy-2- [18F]fluoro-D-glucose-A85380) in humans. Five healthy volunteers without cardiac disease and six patients with either Parkinson's disease or multiple system atrophy without additional overt cardiac disease were evaluated with 2-deoxy-2-[18F]fluoro-D-glucose-A85380 PET-imaging to assess the cardiac parasympathetic innervation and the putative impact of both disorders. 2-deoxy-2- [18F]fluoro-D-glucose-A85380 whole body PET-scans were performed on a Siemens PET/CT biograph(TM) 75.4 min +/- 6.7 after i.v. injection of 371.2 +/- 58.1 MBq. Average count rate density of left ventricle ROI's and a standard ROI in the right lung were measured within three consecutive slices of 10.0 mm thickness. Heart-to-lung ratios were calculated in each volunteer and patient. Tracer uptake in the left ventricle could be measured in all of the five volunteers and the six patients. Heart-to-lung ratios in the volunteer group were not different from patients suffering from Parkinson's disease or MSA (3.2 +/- 0.5 vs 3.2 +/- 0.8 and 2.96+/-0.7, mean +/- SD), respectively. Human cardiac nicotinic acetylcholine receptors can be visualized and measured by 2-deoxy-2- [18F]fluoro-D-glucose-A85380 PET scans both in cardiac-healthy subjects and patients suffering from Parkinson's disease or multiple system atrophy. The heart- as well as the lung-tracer uptake was almost constant throughout all subjects leading to a good target-to-background ratio. These first results suggest no impact of either PD or MSA on cardiac nicotinic acetylcholine receptors.lld:pubmed
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pubmed-article:16598519pubmed:authorpubmed-author:ReinhardtMich...lld:pubmed
pubmed-article:16598519pubmed:authorpubmed-author:BuceriusJanJlld:pubmed
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pubmed-article:16598519pubmed:pagination105-9lld:pubmed
pubmed-article:16598519pubmed:dateRevised2009-11-3lld:pubmed
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pubmed-article:16598519pubmed:year2006lld:pubmed
pubmed-article:16598519pubmed:articleTitleFeasibility of 2-deoxy-2-[18F]fluoro-D-glucose- A85380-PET for imaging of human cardiac nicotinic acetylcholine receptors in vivo.lld:pubmed
pubmed-article:16598519pubmed:affiliationUniversity of Bonn, Department of Nuclear Medicine, Sigmund-Freud-Str. 25, 53105 Bonn, Germany. jan.bucerius@ukb.uni-bonn.delld:pubmed
pubmed-article:16598519pubmed:publicationTypeJournal Articlelld:pubmed