| pubmed-article:1658812 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1658812 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1658812 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:1658812 | lifeskim:mentions | umls-concept:C0001511 | lld:lifeskim |
| pubmed-article:1658812 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:1658812 | lifeskim:mentions | umls-concept:C0023546 | lld:lifeskim |
| pubmed-article:1658812 | lifeskim:mentions | umls-concept:C0038836 | lld:lifeskim |
| pubmed-article:1658812 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:1658812 | lifeskim:mentions | umls-concept:C0243076 | lld:lifeskim |
| pubmed-article:1658812 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:1658812 | lifeskim:mentions | umls-concept:C0074112 | lld:lifeskim |
| pubmed-article:1658812 | lifeskim:mentions | umls-concept:C0083286 | lld:lifeskim |
| pubmed-article:1658812 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1658812 | pubmed:dateCreated | 1991-12-13 | lld:pubmed |
| pubmed-article:1658812 | pubmed:abstractText | Leukotriene B4 (LTB4) induces a number of functional changes in human neutrophils, including both superoxide release and CD11b/CD18 (Mo1)-mediated adherence to various substrates, such as keyhole limpet hemocyanin (KLH). These effects are both time- and concentration-dependent. Neutrophil adhesion was at least 10-fold more sensitive to the stimulatory action of LTB4 than superoxide production. Two LTB4 receptor antagonists, LY255283 (1-(5-ethyl-2-hydroxy-4-(6-methyl-6-(1H-tetrazol-5-yl)heptyloxy )- phenyl)ethanone) and the sodium salt of SC-41930 (7-[3-(4-acetyl-3-methoxy-2-propylphenoxy)-propoxy]-3,4-dihydro-8- propyl-2H- 1-benzopyran-2-carboxylic acid) were evaluated for effects on human neutrophil superoxide production and adhesion. Despite being more sensitive to LTB4-induced stimulation, neutrophil adhesion was at least 100-fold less sensitive to inhibition by LY255283 and SC-41930 than superoxide production. Both LTB4 receptor antagonists behaved similarly in these models. These compounds did not inhibit neutrophil responses induced by granulocyte/macrophage colony-stimulating factor (GM-CSF). | lld:pubmed |
| pubmed-article:1658812 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1658812 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1658812 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1658812 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1658812 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1658812 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1658812 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1658812 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1658812 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1658812 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1658812 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1658812 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1658812 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:1658812 | pubmed:issn | 0952-3278 | lld:pubmed |
| pubmed-article:1658812 | pubmed:author | pubmed-author:SchultzR MRM | lld:pubmed |
| pubmed-article:1658812 | pubmed:author | pubmed-author:SpaetheS MSM | lld:pubmed |
| pubmed-article:1658812 | pubmed:author | pubmed-author:HerronD KDK | lld:pubmed |
| pubmed-article:1658812 | pubmed:author | pubmed-author:SofiaM JMJ | lld:pubmed |
| pubmed-article:1658812 | pubmed:author | pubmed-author:MarderPP | lld:pubmed |
| pubmed-article:1658812 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1658812 | pubmed:volume | 43 | lld:pubmed |
| pubmed-article:1658812 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1658812 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1658812 | pubmed:pagination | 267-71 | lld:pubmed |
| pubmed-article:1658812 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1658812 | pubmed:meshHeading | pubmed-meshheading:1658812-... | lld:pubmed |
| pubmed-article:1658812 | pubmed:meshHeading | pubmed-meshheading:1658812-... | lld:pubmed |
| pubmed-article:1658812 | pubmed:meshHeading | pubmed-meshheading:1658812-... | lld:pubmed |
| pubmed-article:1658812 | pubmed:meshHeading | pubmed-meshheading:1658812-... | lld:pubmed |
| pubmed-article:1658812 | pubmed:meshHeading | pubmed-meshheading:1658812-... | lld:pubmed |
| pubmed-article:1658812 | pubmed:meshHeading | pubmed-meshheading:1658812-... | lld:pubmed |
| pubmed-article:1658812 | pubmed:meshHeading | pubmed-meshheading:1658812-... | lld:pubmed |
| pubmed-article:1658812 | pubmed:meshHeading | pubmed-meshheading:1658812-... | lld:pubmed |
| pubmed-article:1658812 | pubmed:meshHeading | pubmed-meshheading:1658812-... | lld:pubmed |
| pubmed-article:1658812 | pubmed:meshHeading | pubmed-meshheading:1658812-... | lld:pubmed |
| pubmed-article:1658812 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1658812 | pubmed:articleTitle | Effects of two leukotriene B4 (LTB4) receptor antagonists (LY255283 and SC-41930) on LTB4-induced human neutrophil adhesion and superoxide production. | lld:pubmed |
| pubmed-article:1658812 | pubmed:affiliation | Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285. | lld:pubmed |
| pubmed-article:1658812 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1658812 | pubmed:publicationType | In Vitro | lld:pubmed |
