| pubmed-article:1658727 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1658727 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:1658727 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:1658727 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:1658727 | lifeskim:mentions | umls-concept:C0086376 | lld:lifeskim |
| pubmed-article:1658727 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:1658727 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:1658727 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:1658727 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:1658727 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:1658727 | lifeskim:mentions | umls-concept:C0599668 | lld:lifeskim |
| pubmed-article:1658727 | lifeskim:mentions | umls-concept:C0599756 | lld:lifeskim |
| pubmed-article:1658727 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:1658727 | pubmed:dateCreated | 1991-11-25 | lld:pubmed |
| pubmed-article:1658727 | pubmed:abstractText | Effects of acetylcholine (ACh) and noradrenaline (NA) on voltage-gated ion channels of sympathetic neurones acutely dissociated from rat superior cervical ganglion (SCG) were examined using the whole-cell voltage-clamp technique. Depolarizing voltage steps elicited two types of low- and high-voltage-activated (LVA and HVA) Ca2+ currents. Pressure applications of ACh and NA produced concentration-dependent inhibition of the HVA Ca2+ current without affecting the LVA Ca2+ current. The inhibitory action of ACh on the Ca2+ current was blocked by a muscarinic antagonist, atropine. The action of NA was suppressed by an alpha 2-adrenergic antagonist, yohimbine, but not by an alpha 1-adrenergic antagonist, prazosin. Delayed rectifying outward K+ currents and inward rectifying K+ current were not affected by either ACh or NA. Tetrodotoxin-sensitive and -insensitive Na+ currents also remained unaffected under actions of ACh and NA. When recorded with electrode containing guanosine-5'-O-(3-thiotriphosphate) (GTP-gamma-S), the inhibitory actions of ACh and NA on Ca2+ currents became irreversible. After treatment of SCG neurones with pertussis toxin, the inhibitory action of ACh on the Ca2+ current was almost completely abolished, whereas the action of NA was only partially reduced. The results suggest that ACh and NA differentially inhibit the HVA Ca2+ current via different G proteins coupling muscarinic and alpha 2-adrenergic receptors to Ca2+ channels in rat SCG neurones. | lld:pubmed |
| pubmed-article:1658727 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1658727 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1658727 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1658727 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1658727 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1658727 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1658727 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1658727 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1658727 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1658727 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:1658727 | pubmed:issn | 0031-6768 | lld:pubmed |
| pubmed-article:1658727 | pubmed:author | pubmed-author:SaitoKK | lld:pubmed |
| pubmed-article:1658727 | pubmed:author | pubmed-author:KonishiSS | lld:pubmed |
| pubmed-article:1658727 | pubmed:author | pubmed-author:SongS YSY | lld:pubmed |
| pubmed-article:1658727 | pubmed:author | pubmed-author:NoguchiKK | lld:pubmed |
| pubmed-article:1658727 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1658727 | pubmed:volume | 418 | lld:pubmed |
| pubmed-article:1658727 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1658727 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1658727 | pubmed:pagination | 592-600 | lld:pubmed |
| pubmed-article:1658727 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:1658727 | pubmed:meshHeading | pubmed-meshheading:1658727-... | lld:pubmed |
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| pubmed-article:1658727 | pubmed:meshHeading | pubmed-meshheading:1658727-... | lld:pubmed |
| pubmed-article:1658727 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1658727 | pubmed:articleTitle | Adrenergic and cholinergic inhibition of Ca2+ channels mediated by different GTP-binding proteins in rat sympathetic neurones. | lld:pubmed |
| pubmed-article:1658727 | pubmed:affiliation | Laboratory of Cellular Physiology, Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan. | lld:pubmed |
| pubmed-article:1658727 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1658727 | pubmed:publicationType | In Vitro | lld:pubmed |
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