| pubmed-article:16585553 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16585553 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:16585553 | lifeskim:mentions | umls-concept:C0017349 | lld:lifeskim |
| pubmed-article:16585553 | lifeskim:mentions | umls-concept:C0039198 | lld:lifeskim |
| pubmed-article:16585553 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16585553 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:16585553 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:16585553 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:16585553 | pubmed:dateCreated | 2006-4-4 | lld:pubmed |
| pubmed-article:16585553 | pubmed:abstractText | It has been known for decades that circulating human CD4 cells can express functional MHC class II molecules that induce T cell nonresponsiveness with Ag presentation. Because there is significant expression of MHC class II (MHC-II) determinants (DR) on a subpopulation CD4+ CD25(high) regulatory T cells (Treg), we examined the function of CD4 cells expressing MHC-DR. We demonstrate that MHC-II expression on human CD4+ CD25(high) T cells identifies a functionally distinct population of Treg that induces early contact-dependent suppression that is associated with high Foxp3 expression. In striking contrast, MHC-II- CD4+ CD25(high) Treg induce early IL-4 and IL-10 secretion and a late Foxp3-associated contact-dependent suppression. The DR expressing CD25(high) Treg express higher levels of Foxp3 message and protein, compared with the DR- CD25(high) Treg population. Direct single-cell cloning of CD4+ CD25(high) Treg revealed that, regardless of initial DR expression, ex vivo expression of CD25(high), and not DR, predicted which clones would exhibit contact-dependent suppression, high levels of Foxp3 message, and an increased propensity to become constitutive for DR expression. Thus, the direct ex vivo expression of MHC-II in the context of CD25(high) identifies a mature, functionally distinct regulatory T cell population involved in contact-dependent in vitro suppression. | lld:pubmed |
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| pubmed-article:16585553 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16585553 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16585553 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:16585553 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16585553 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16585553 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:16585553 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:16585553 | pubmed:author | pubmed-author:HaflerDavid... | lld:pubmed |
| pubmed-article:16585553 | pubmed:author | pubmed-author:Baecher-Allan... | lld:pubmed |
| pubmed-article:16585553 | pubmed:author | pubmed-author:WolfElizabeth... | lld:pubmed |
| pubmed-article:16585553 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16585553 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16585553 | pubmed:volume | 176 | lld:pubmed |
| pubmed-article:16585553 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16585553 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16585553 | pubmed:pagination | 4622-31 | lld:pubmed |
| pubmed-article:16585553 | pubmed:dateRevised | 2008-6-10 | lld:pubmed |
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| pubmed-article:16585553 | pubmed:meshHeading | pubmed-meshheading:16585553... | lld:pubmed |
| pubmed-article:16585553 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16585553 | pubmed:articleTitle | MHC class II expression identifies functionally distinct human regulatory T cells. | lld:pubmed |
| pubmed-article:16585553 | pubmed:affiliation | Laboratory of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA. callan@rics.bwh.harvard.edu | lld:pubmed |
| pubmed-article:16585553 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16585553 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:16585553 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16585553 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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