| pubmed-article:16583457 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16583457 | lifeskim:mentions | umls-concept:C0152035 | lld:lifeskim |
| pubmed-article:16583457 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:16583457 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:16583457 | lifeskim:mentions | umls-concept:C0025663 | lld:lifeskim |
| pubmed-article:16583457 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
| pubmed-article:16583457 | lifeskim:mentions | umls-concept:C0302908 | lld:lifeskim |
| pubmed-article:16583457 | lifeskim:mentions | umls-concept:C0001563 | lld:lifeskim |
| pubmed-article:16583457 | lifeskim:mentions | umls-concept:C0680730 | lld:lifeskim |
| pubmed-article:16583457 | lifeskim:mentions | umls-concept:C1521827 | lld:lifeskim |
| pubmed-article:16583457 | lifeskim:mentions | umls-concept:C0201734 | lld:lifeskim |
| pubmed-article:16583457 | lifeskim:mentions | umls-concept:C1148554 | lld:lifeskim |
| pubmed-article:16583457 | lifeskim:mentions | umls-concept:C1548559 | lld:lifeskim |
| pubmed-article:16583457 | lifeskim:mentions | umls-concept:C1869987 | lld:lifeskim |
| pubmed-article:16583457 | lifeskim:mentions | umls-concept:C1258284 | lld:lifeskim |
| pubmed-article:16583457 | lifeskim:mentions | umls-concept:C0443324 | lld:lifeskim |
| pubmed-article:16583457 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:16583457 | pubmed:dateCreated | 2006-10-26 | lld:pubmed |
| pubmed-article:16583457 | pubmed:abstractText | A high-performance liquid chromatographic method for the determination of wogonoside in plasma of rats administrated orally with the traditional Chinese medicinal preparation Huang-Lian-Jie-Du decoction was developed. Sample preparation was carried out by protein precipitation with a mixture of acetonitrile and methanol (1:1, v/v). The extracted sample was separated on a Hypersil C(18) (150 x 5 mm i.d., 5 microm) analytical column by linear gradient elution using 0.05% (v/v) phosphoric acid (containing 5 mm sodium dihydrogen phosphate) and acetonitrile as mobile phase at a flow rate of 1.5 mL/min. The eluate was detected using a UV detector at 276 nm. The assay was linear over the range 0.109-7.0 microg/mL (R(2) = 0.9999, n = 5). Mean recovery was determined as 98.39%. Intra- and inter-day precisions (RSD) were < or =7.59%. The limit of quantitation was 0.109 microg/mL. After validation, the HPLC method developed was applied to investigate the preliminary pharmacokinetics of wogonoside in rat after oral administration of Huang-Lian-Jie-Du decoction. | lld:pubmed |
| pubmed-article:16583457 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16583457 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16583457 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16583457 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16583457 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16583457 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16583457 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16583457 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:16583457 | pubmed:issn | 0269-3879 | lld:pubmed |
| pubmed-article:16583457 | pubmed:author | pubmed-author:SzeS HSH | lld:pubmed |
| pubmed-article:16583457 | pubmed:author | pubmed-author:LuTongT | lld:pubmed |
| pubmed-article:16583457 | pubmed:author | pubmed-author:LiuXiao-DongX... | lld:pubmed |
| pubmed-article:16583457 | pubmed:author | pubmed-author:DengYuan-Xion... | lld:pubmed |
| pubmed-article:16583457 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16583457 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:16583457 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16583457 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16583457 | pubmed:pagination | 1098-102 | lld:pubmed |
| pubmed-article:16583457 | pubmed:meshHeading | pubmed-meshheading:16583457... | lld:pubmed |
| pubmed-article:16583457 | pubmed:meshHeading | pubmed-meshheading:16583457... | lld:pubmed |
| pubmed-article:16583457 | pubmed:meshHeading | pubmed-meshheading:16583457... | lld:pubmed |
| pubmed-article:16583457 | pubmed:meshHeading | pubmed-meshheading:16583457... | lld:pubmed |
| pubmed-article:16583457 | pubmed:meshHeading | pubmed-meshheading:16583457... | lld:pubmed |
| pubmed-article:16583457 | pubmed:meshHeading | pubmed-meshheading:16583457... | lld:pubmed |
| pubmed-article:16583457 | pubmed:meshHeading | pubmed-meshheading:16583457... | lld:pubmed |
| pubmed-article:16583457 | pubmed:meshHeading | pubmed-meshheading:16583457... | lld:pubmed |
| pubmed-article:16583457 | pubmed:meshHeading | pubmed-meshheading:16583457... | lld:pubmed |
| pubmed-article:16583457 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16583457 | pubmed:articleTitle | High-performance liquid chromatographic method for the determination and pharmacokinetic study of wogonoside in rat serum after oral administration of traditional Chinese medicinal preparation Huang-Lian-Jie-Du decoction. | lld:pubmed |
| pubmed-article:16583457 | pubmed:affiliation | Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Tongjiaxiang 24, Nanjing 210009, Jiangsu, People's Republic of China. | lld:pubmed |
| pubmed-article:16583457 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16583457 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16583457 | lld:pubmed |
