| pubmed-article:16581799 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16581799 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:16581799 | lifeskim:mentions | umls-concept:C0017526 | lld:lifeskim |
| pubmed-article:16581799 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:16581799 | lifeskim:mentions | umls-concept:C0041178 | lld:lifeskim |
| pubmed-article:16581799 | lifeskim:mentions | umls-concept:C0311400 | lld:lifeskim |
| pubmed-article:16581799 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:16581799 | lifeskim:mentions | umls-concept:C1418776 | lld:lifeskim |
| pubmed-article:16581799 | lifeskim:mentions | umls-concept:C1705241 | lld:lifeskim |
| pubmed-article:16581799 | lifeskim:mentions | umls-concept:C0439097 | lld:lifeskim |
| pubmed-article:16581799 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:16581799 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:16581799 | lifeskim:mentions | umls-concept:C1547348 | lld:lifeskim |
| pubmed-article:16581799 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:16581799 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:16581799 | pubmed:dateCreated | 2006-4-3 | lld:pubmed |
| pubmed-article:16581799 | pubmed:abstractText | Mutation of the nuclear receptor peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) severely affects placenta development, leading to embryonic death at embryonic day 9.5 (E9.5) to E10.5 of most, but not all, PPARbeta/delta-null mutant embryos. While very little is known at present about the pathway governed by PPARbeta/delta in the developing placenta, this paper demonstrates that the main alteration of the placenta of PPARbeta/delta-null embryos is found in the giant cell layer. PPARbeta/delta activity is in fact essential for the differentiation of the Rcho-1 cells in giant cells, as shown by the severe inhibition of differentiation once PPARbeta/delta is silenced. Conversely, exposure of Rcho-1 cells to a PPARbeta/delta agonist triggers a massive differentiation via increased expression of 3-phosphoinositide-dependent kinase 1 and integrin-linked kinase and subsequent phosphorylation of Akt. The links between PPARbeta/delta activity in giant cells and its role on Akt activity are further strengthened by the remarkable pattern of phospho-Akt expression in vivo at E9.5, specifically in the nucleus of the giant cells. In addition to this phosphatidylinositol 3-kinase/Akt main pathway, PPARbeta/delta also induced giant cell differentiation via increased expression of I-mfa, an inhibitor of Mash-2 activity. Finally, giant cell differentiation at E9.5 is accompanied by a PPARbeta/delta-dependent accumulation of lipid droplets and an increased expression of the adipose differentiation-related protein (also called adipophilin), which may participate to lipid metabolism and/or steroidogenesis. Altogether, this important role of PPARbeta/delta in placenta development and giant cell differentiation should be considered when contemplating the potency of PPARbeta/delta agonist as therapeutic agents of broad application. | lld:pubmed |
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| pubmed-article:16581799 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16581799 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16581799 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16581799 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16581799 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16581799 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:16581799 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:16581799 | pubmed:author | pubmed-author:WahliWalterW | lld:pubmed |
| pubmed-article:16581799 | pubmed:author | pubmed-author:TronoDidierD | lld:pubmed |
| pubmed-article:16581799 | pubmed:author | pubmed-author:DesvergneBéat... | lld:pubmed |
