Linked Life Data

16581022

Source:http://linkedlifedata.com/resource/pubmed/id/16581022

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SubjectPredicateObjectContext
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pubmed-article:16581022pubmed:dateCreated2006-4-26lld:pubmed
pubmed-article:16581022pubmed:abstractTextWe have sequenced a 4.9kb clone (KLB22) which shares 99% sequence homology with the rabbit vasopressin-activated calcium mobilizing (VACM-1) protein. The 5' terminus sequence of KLB22 cDNA (nucleotides 1-1961) is continuous and overlapping with nucleotides 1226-3186 of the VACM-1 cDNA sequence. The 3'UTR of KLB22 cDNA extends beyond the 3'UTR of VACM-1 by 2999nt. KLB22 cDNA encodes a 497 amino acid protein, which putatively begins at Met 284 of the 780 amino acid VACM-1 protein. The in vitro translation of KLB22 cDNA yields a 59kDa protein. When expressed in cos-1 cells, the truncated VACM-1 protein localizes to the nucleus. KLB22 cDNA transfected cells show increased growth rates and increased levels of phosphorylated MAPK when compared to the vector or to VACM-1 cDNA transfected cells. Finally, in vivo, KLB22 protein expression is tissue specific and can be detected in kidney and in heart atrium. These results suggest that truncated VACM-1 cDNA (KLB22) increases cell proliferation through a MAPK pathway.lld:pubmed
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pubmed-article:16581022pubmed:pagination1086-93lld:pubmed
pubmed-article:16581022pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:16581022pubmed:year2006lld:pubmed
pubmed-article:16581022pubmed:articleTitleTruncated form of VACM-1/cul-5 with an extended 3' untranslated region stimulates cell growth via a MAPK-dependent pathway.lld:pubmed
pubmed-article:16581022pubmed:affiliationDepartments of Biology and Chemistry, Hope College, Holland, MI 49423, USA.lld:pubmed
pubmed-article:16581022pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16581022pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
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