| pubmed-article:1658045 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1658045 | lifeskim:mentions | umls-concept:C0020538 | lld:lifeskim |
| pubmed-article:1658045 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:1658045 | lifeskim:mentions | umls-concept:C0003765 | lld:lifeskim |
| pubmed-article:1658045 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1658045 | pubmed:dateCreated | 1991-12-13 | lld:pubmed |
| pubmed-article:1658045 | pubmed:abstractText | This study examined the contribution of nitric oxide (NO) to the susceptibility or resistance to the hypertensive effects of high sodium chloride (8.0% NaCl) intake in young Dahl/Rapp salt-sensitive (SS/Jr) and salt-resistant (SR/Jr) rats. Using NG-monomethyl-L-arginine (L-NMMA) as a probe for NO production in vivo, we found that increasing dietary sodium chloride increased NO activity in salt-resistant rats, but not in salt-sensitive rats. Exogenous L-arginine, the substrate for NO synthesis, decreased blood pressure to normotensive levels in salt-sensitive rats made hypertensive for 2 wk from 8.0% NaCl chow. D-arginine had no effect on blood pressure of these rats and L-arginine did not change blood pressure of salt-resistant rats. Intraperitoneal injections of L-arginine and its precursor, L-citrulline, and oral L-arginine, but not D-arginine, prevented the increase in blood pressure in salt-sensitive rats on the high salt chow over 2 wk of observation. In contrast, L-arginine did not alter the development of hypertension in spontaneously hypertensive rats. Mean urinary cGMP levels were higher in salt-sensitive rats on oral L-arginine than salt-sensitive rats on D-arginine. Infusion of L-NMMA acutely decreased, whereas intravenous L-arginine rapidly increased, urinary cGMP in both groups. L-arginine and L-citrulline increased production of NO and prevented salt-sensitive hypertension in Dahl/Rapp rats. | lld:pubmed |
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| pubmed-article:1658045 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:1658045 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:1658045 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1658045 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1658045 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:1658045 | pubmed:author | pubmed-author:SandersP WPW | lld:pubmed |
| pubmed-article:1658045 | pubmed:author | pubmed-author:ChenP YPY | lld:pubmed |
| pubmed-article:1658045 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1658045 | pubmed:volume | 88 | lld:pubmed |
| pubmed-article:1658045 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1658045 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1658045 | pubmed:pagination | 1559-67 | lld:pubmed |
| pubmed-article:1658045 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1658045 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1658045 | pubmed:articleTitle | L-arginine abrogates salt-sensitive hypertension in Dahl/Rapp rats. | lld:pubmed |
| pubmed-article:1658045 | pubmed:affiliation | Nephrology Research and Training Center, University of Alabama, Birmingham 35294. | lld:pubmed |
| pubmed-article:1658045 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1658045 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1658045 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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