| pubmed-article:1657988 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1657988 | lifeskim:mentions | umls-concept:C0086934 | lld:lifeskim |
| pubmed-article:1657988 | lifeskim:mentions | umls-concept:C0080124 | lld:lifeskim |
| pubmed-article:1657988 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:1657988 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:1657988 | pubmed:issue | 33 | lld:pubmed |
| pubmed-article:1657988 | pubmed:dateCreated | 1991-12-26 | lld:pubmed |
| pubmed-article:1657988 | pubmed:abstractText | The rat erbA alpha locus encodes two overlapping mRNAs, alpha 1 and alpha 2, which are identical except for their most 3' exons. alpha 1 mRNA encodes a thyroid hormone receptor, while alpha 2 encodes an altered ligand binding domain of unknown function. Previous studies have shown that the ratio of alpha 1 to alpha 2 is highest in cells expressing a high level of a third RNA, Rev-ErbA alpha mRNA, which is transcribed in the opposite direction and is complementary to alpha 2 but not alpha 1 mRNA. It was hypothesized that base pairing with Rev-ErbA alpha blocks splicing of alpha 2 mRNA, thereby favoring formation of the non-overlapping alpha 1. To test this model, a system was developed in which alpha 2 pre-mRNAs were accurately spliced in vitro. Splicing was inhibited by the addition of a 5-fold excess of antisense RNAs containing the 3' end of Rev-ErbA alpha mRNA. Both an antisense RNA extending across the 3' splice site and a shorter RNA complementary only to exon sequences efficiently blocked splicing. However, splicing was only inhibited by complementary RNAs. These observations are consistent with a mechanism in which base pairing with a complementary RNA regulates alternative processing of alpha 1 and alpha 2 mRNAs. | lld:pubmed |
| pubmed-article:1657988 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1657988 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1657988 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1657988 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1657988 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1657988 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1657988 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1657988 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:1657988 | pubmed:author | pubmed-author:LazarM AMA | lld:pubmed |
| pubmed-article:1657988 | pubmed:author | pubmed-author:MunroeS HSH | lld:pubmed |
| pubmed-article:1657988 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1657988 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:1657988 | pubmed:volume | 266 | lld:pubmed |
| pubmed-article:1657988 | pubmed:geneSymbol | c-erbA | lld:pubmed |
| pubmed-article:1657988 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1657988 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1657988 | pubmed:pagination | 22083-6 | lld:pubmed |
| pubmed-article:1657988 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:1657988 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1657988 | pubmed:articleTitle | Inhibition of c-erbA mRNA splicing by a naturally occurring antisense RNA. | lld:pubmed |
| pubmed-article:1657988 | pubmed:affiliation | Department of Biology, Marquette University, Milwaukee, Wisconsin 53233. | lld:pubmed |
| pubmed-article:1657988 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1657988 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1657988 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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