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pubmed-article:1657884pubmed:abstractTextRibosomal resistance to pactamycin in clones of Streptomyces lividans containing DNA (pct) from Streptomyces pactum, the pactamycin producer, involves methylation of 16S RNA. The modified residue A-941 in S. lividans 16S rRNA (A-964 in the homologous Escherichia coli sequence) is converted to 1-methyladenosine, and the ribosomal ability to bind pactamycin is reduced or abolished.lld:pubmed
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pubmed-article:1657884pubmed:articleTitleSite-specific methylation of 16S rRNA caused by pct, a pactamycin resistance determinant from the producing organism, Streptomyces pactum.lld:pubmed
pubmed-article:1657884pubmed:affiliationCentro de Biologia Molecular, Consejo Superior de Investigaciones Científicas, Canto Blanco, Madrid, Spain.lld:pubmed
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