| pubmed-article:16570050 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16570050 | lifeskim:mentions | umls-concept:C0006118 | lld:lifeskim |
| pubmed-article:16570050 | lifeskim:mentions | umls-concept:C1327616 | lld:lifeskim |
| pubmed-article:16570050 | lifeskim:mentions | umls-concept:C0030946 | lld:lifeskim |
| pubmed-article:16570050 | lifeskim:mentions | umls-concept:C0596087 | lld:lifeskim |
| pubmed-article:16570050 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16570050 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:16570050 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:16570050 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:16570050 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:16570050 | pubmed:dateCreated | 2006-4-19 | lld:pubmed |
| pubmed-article:16570050 | pubmed:abstractText | Angiogenesis and extracellular matrix degradation are key events in tumour progression, and factors regulating stromal-epithelial interactions and matrix composition are potential targets for the development of novel anti-invasive/antiangiogenic therapies. Here, we examine the expression of ADAMTS-8, a secreted protease with antiangiogenic properties, in brain tissues. Using quantitative RT-polymerase chain reaction (PCR), high, equivalent expression of ADAMTS-8 was found in normal whole brain, cerebral cortex, frontal lobe, cerebellum and meninges. ADAMTS-8 expression in 34 brain tumours (including 22 high-grade gliomas) and four glioma cell lines indicated at least two-fold reduction in mRNA compared to normal whole brain in all neoplastic tissues, and no detectable expression in 14 out of 34 (41%) tumours or four out of four (100%) cell lines. In contrast, differential expression of TSP1 and VEGF was seen in nine out of 15 (60%) and seven out of 13 (54%) tumours, with no relationship in the expression of these genes. Immunohistochemistry and Western analysis indicated downregulation of ADAMTS-8 protein in >77% tumours. Methylation-specific PCR analysis of ADAMTS-8 indicated promoter hypermethylation in one out of 24 brain tumours (a metastasis) and three out of four glioma cell lines suggesting an alternative mechanism of downregulation. These data suggest a role for ADAMTS-8 in brain tumorigenesis, warranting further investigation into its role in regulation of tumour angiogenesis and local invasion. | lld:pubmed |
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| pubmed-article:16570050 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16570050 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16570050 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16570050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16570050 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16570050 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:16570050 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:16570050 | pubmed:author | pubmed-author:ReevesPP | lld:pubmed |
| pubmed-article:16570050 | pubmed:author | pubmed-author:ShawE JEJ | lld:pubmed |
| pubmed-article:16570050 | pubmed:author | pubmed-author:ReedJ EJE | lld:pubmed |
| pubmed-article:16570050 | pubmed:author | pubmed-author:WalkerCC | lld:pubmed |
| pubmed-article:16570050 | pubmed:author | pubmed-author:DunnJ RJR | lld:pubmed |
| pubmed-article:16570050 | pubmed:author | pubmed-author:WarnkePP | lld:pubmed |
| pubmed-article:16570050 | pubmed:author | pubmed-author:GeeA LAL | lld:pubmed |
| pubmed-article:16570050 | pubmed:author | pubmed-author:du PlessisD... | lld:pubmed |
| pubmed-article:16570050 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16570050 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:16570050 | pubmed:volume | 94 | lld:pubmed |
| pubmed-article:16570050 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16570050 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16570050 | pubmed:pagination | 1186-93 | lld:pubmed |
| pubmed-article:16570050 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:16570050 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16570050 | pubmed:articleTitle | Expression of ADAMTS-8, a secreted protease with antiangiogenic properties, is downregulated in brain tumours. | lld:pubmed |
| pubmed-article:16570050 | pubmed:affiliation | JK Douglas Cancer Research Laboratories, Clatterbridge Hospital, Bebington, Wirral CH64 3JY, and Department of Neurological Science, University of Liverpool, UK. julie.dunn@ccrt.nhs.uk | lld:pubmed |
| pubmed-article:16570050 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16570050 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:16570050 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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