| pubmed-article:16569767 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16569767 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:16569767 | lifeskim:mentions | umls-concept:C0254610 | lld:lifeskim |
| pubmed-article:16569767 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:16569767 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:16569767 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:16569767 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16569767 | pubmed:dateCreated | 2006-7-6 | lld:pubmed |
| pubmed-article:16569767 | pubmed:abstractText | Although interleukin 2 (IL-2) and IL-15 signal through the common gamma chain (gammac) and through IL-2 receptor beta-chain (CD122) subunits, they direct distinct physiologic and immunotherapeutic responses in T cells. The present study provides some insight into why IL-2 and IL-15 differentially regulate T-cell function by revealing that these cytokines are strikingly distinct in their ability to control protein synthesis and T-cell mass. IL-2 and IL-15 are shown to be equivalent mitogens for antigen-stimulated CD8(+) T cells but not for equivalent growth factors. Antigen-primed T cells cannot autonomously maintain amino acid incorporation or de novo protein synthesis without exogenous cytokine stimulation. Both IL-2 and IL-15 induce amino acid uptake and protein synthesis in antigen-activated T cells; however, the IL-2 response is strikingly more potent than the IL-15 response. The differential action of IL-2 and IL-15 on amino acid uptake and protein synthesis is explained by temporal differences in signaling induced by these 2 cytokines. Hence, the present results show that cytokines that are equivalent mitogens can have different potency in terms of regulating protein synthesis and cell growth. | lld:pubmed |
| pubmed-article:16569767 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16569767 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16569767 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:16569767 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16569767 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16569767 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16569767 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16569767 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:16569767 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:16569767 | pubmed:author | pubmed-author:CantrellDoree... | lld:pubmed |
| pubmed-article:16569767 | pubmed:author | pubmed-author:CornishGeorgi... | lld:pubmed |
| pubmed-article:16569767 | pubmed:author | pubmed-author:SinclairLinda... | lld:pubmed |
| pubmed-article:16569767 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16569767 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16569767 | pubmed:volume | 108 | lld:pubmed |
| pubmed-article:16569767 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16569767 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16569767 | pubmed:pagination | 600-8 | lld:pubmed |
| pubmed-article:16569767 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:16569767 | pubmed:meshHeading | pubmed-meshheading:16569767... | lld:pubmed |
| pubmed-article:16569767 | pubmed:meshHeading | pubmed-meshheading:16569767... | lld:pubmed |
| pubmed-article:16569767 | pubmed:meshHeading | pubmed-meshheading:16569767... | lld:pubmed |
| pubmed-article:16569767 | pubmed:meshHeading | pubmed-meshheading:16569767... | lld:pubmed |
| pubmed-article:16569767 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16569767 | pubmed:articleTitle | Differential regulation of T-cell growth by IL-2 and IL-15. | lld:pubmed |
| pubmed-article:16569767 | pubmed:affiliation | Cancer Research UK, London, England. | lld:pubmed |
| pubmed-article:16569767 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16569767 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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